ADCY1 and GNAI2

Number of citations of the paper that reports this interaction (PMID 2121366)
11

Data Source:
HPRD (in vivo)

		ADCY1	GNAI2
Gene Name		adenylate cyclase 1 (brain)	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Metal Ion Binding	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Axonogenesis Long-term Memory Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Response To Lithium Ion Activation Of Protein Kinase A Activity Intracellular Signal Transduction Response To Drug Regulation Of Circadian Rhythm Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Cellular Response To Glucagon Stimulus	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR Post NMDA receptor activation events Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs		Adenosine monophosphate Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ADCY2 GNAI2	64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A
Entrez ID		107	2771
HPRD ID		00053	00764
Ensembl ID		ENSG00000164742	ENSG00000114353
Uniprot IDs		C9J1J0 Q08828 Q59FG4 Q8NFM5	B3KP24 B3KX51 P04899
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Synaptic Transmission Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Adenosine Receptor Signaling Pathway Regulation Of Kinase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Activation Of Protein Kinase A Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cell-cell Signaling CAMP Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Renal Water Homeostasis G-protein Coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Protein Metabolic Process CAMP Metabolic Process Regulation Of Phosphorylation Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Cyclic Purine Nucleotide Metabolic Process Water Transport Fluid Transport Regulation Of Phosphorus Metabolic Process Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Catalytic Activity Cyclic Nucleotide Biosynthetic Process Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Water Homeostasis Negative Regulation Of Synaptic Transmission Activation Of MAPKK Activity Regulation Of Cyclase Activity Cyclic Nucleotide Metabolic Process	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity
Tagcloud ?			aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?			aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?