ADCY1 and SERTAD1

Number of citations of the paper that reports this interaction (PubMedID 28656888)
65

Data Source:
BioGRID (enzymatic study)

		ADCY1	SERTAD1
Description		adenylate cyclase 1	SERTA domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Membrane Raft Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm Sarcoplasm
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Long-term Memory Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Regulation Of Circadian Rhythm Rhythmic Process Modulation Of Chemical Synaptic Transmission Cellular Response To Calcium Ion Presynaptic Modulation Of Chemical Synaptic Transmission Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Forskolin	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Adenosine phosphate ATP Hyoscyamine Colforsin Aurothioglucose
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Night sleep phenotypes ( 27126917) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Monocyte percentage of white cells ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		4 interacting genes: ADCY2 FZD7 GNAI2 SERTAD1	56 interacting genes: ADCY1 AIRIM ASB8 ATG12 ATXN7L3 BANF2 CCND2 CDK4 CDKN2A CHAF1A CHURC1 CIB3 CINP CKS1B COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAAP20 FAH FNDC11 FXR1 GLYCTK HIVEP1 HSPB1 KAT2B KLC4 KLHL42 MVP P4HA3 PATE1 PBX4 PICK1 PIH1D2 POT1 PRDM4 PSORS1C2 RBX1 RCHY1 ROPN1 SEC14L4 SETD7 SFI1 SMAD3 SPEN SSX7 STAT5B SUPT7L TGM2 TLR4 TRIM28 TSC1 XIAP ZNF410
Entrez ID		107	29950
HPRD ID		00053	15326
Ensembl ID		ENSG00000164742	ENSG00000197019
Uniprot IDs		C9J1J0 Q08828	Q53GC0 Q9UHV2
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphorus-oxygen Lyase Activity Dendrite Response To Forskolin Adenylate Cyclase Binding CAMP Biosynthetic Process Cellular Response To Forskolin Adenylate Cyclase Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Lipid G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of MAPK Cascade Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Regulation Of Cell Population Proliferation Neuronal Dense Core Vesicle Cell Division G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Somatic Stem Cell Division Negative Regulation Of Cell Fate Commitment Wnt Receptor Activity Regulation Of Cardiac Muscle Cell Differentiation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Negative Regulation Of Ectodermal Cell Fate Specification Regulation Of Phosphorylation Negative Regulation Of Cardiocyte Differentiation Mesenchymal To Epithelial Transition Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Negative Regulation Of Cardiac Muscle Cell Differentiation Sarcoplasm CAMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Stem Cell Division Regulation Of Cell Fate Specification Gamma-aminobutyric Acid Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Wnt-protein Binding	N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Histone H3K27 Acetyltransferase Activity Regulation Of DNA Repair Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Localization To Nucleus Protein Binding Cellular Response To Stress Cyclin D2-CDK4 Complex Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Nucleus Protein Modification Process DNA Damage Response Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Complex Transcription Coregulator Activity SAGA Complex Protein-lysine-acetyltransferase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Stabilization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Chromatin Regulation Of Protein Localization To Nucleus Chromatin Binding Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Chromo Shadow Domain Binding Protein Acetylation Cellular Response To Nutrient Levels Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Positive Regulation Of Protein Import Into Nucleus
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