ADCY1 and ADCY2

Number of citations of the paper that reports this interaction (PMID 8692867)
26

Data Source:
HPRD (in vitro)

		ADCY1	ADCY2
Gene Name		adenylate cyclase 1 (brain)	adenylate cyclase 2 (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Intracellular Cytoplasm Plasma Membrane Membrane Integral Component Of Membrane Dendrite Protein Complex Membrane Raft
	Molecular Function	Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Metal Ion Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Axonogenesis Long-term Memory Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Response To Lithium Ion Activation Of Protein Kinase A Activity Intracellular Signal Transduction Response To Drug Regulation Of Circadian Rhythm Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Cellular Response To Glucagon Stimulus	Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR Post NMDA receptor activation events Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling	Signaling by GPCR Ca-dependent events CaM pathway Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs		Adenosine monophosphate Adenosine triphosphate
Diseases
GWAS			Capecitabine sensitivity ( 22864933) Visceral fat ( 22589738)
Protein-Protein Interactions		2 interactors: ADCY2 GNAI2	3 interactors: ADCY1 ADCY5 GNAS
Entrez ID		107	108
HPRD ID		00053	00052
Ensembl ID		ENSG00000164742	ENSG00000078295
Uniprot IDs		C9J1J0 Q08828 Q59FG4 Q8NFM5	Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Synaptic Transmission Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Adenosine Receptor Signaling Pathway Regulation Of Kinase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Activation Of Protein Kinase A Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cell-cell Signaling CAMP Biosynthetic Process Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Renal Water Homeostasis G-protein Coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Protein Metabolic Process CAMP Metabolic Process Regulation Of Phosphorylation Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Cyclic Purine Nucleotide Metabolic Process Water Transport Fluid Transport Regulation Of Phosphorus Metabolic Process Multicellular Organismal Water Homeostasis Activation Of Phospholipase C Activity Positive Regulation Of Catalytic Activity Cyclic Nucleotide Biosynthetic Process Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Water Homeostasis Negative Regulation Of Synaptic Transmission Activation Of MAPKK Activity Regulation Of Cyclase Activity Cyclic Nucleotide Metabolic Process	CAMP Biosynthetic Process Renal Water Homeostasis CAMP Metabolic Process Cellular Response To Glucagon Stimulus Cyclic Purine Nucleotide Metabolic Process Water Transport Fluid Transport Cyclic Nucleotide Biosynthetic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Water Homeostasis Response To Glucagon Water Homeostasis Cyclic Nucleotide Metabolic Process Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Activation Of Protein Kinase A Activity Ribonucleotide Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Cellular Response To Peptide Hormone Stimulus Ribose Phosphate Metabolic Process Cellular Response To Peptide Dopamine Receptor Signaling Pathway Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Activation Of Phospholipase C Activity Nucleotide Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Positive Regulation Of Phospholipase C Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Response To Organonitrogen Compound Chemical Homeostasis Response To Hormone Organophosphate Metabolic Process Positive Regulation Of Hydrolase Activity G-protein Coupled Receptor Signaling Pathway Neurological System Process
Tagcloud ?			acaca actn1 adni analysing cr1 describing endophenotype exploits finite gnai1 grouped initiative jointly kegg lasso neuroimaging penalised pik3cg pik3r3 prkcaandprkcb psrrr ranked ranking resampling sparse tomm40 uses voxel wise
Tagcloud (Difference) ?			acaca actn1 adni analysing cr1 describing endophenotype exploits finite gnai1 grouped initiative jointly kegg lasso neuroimaging penalised pik3cg pik3r3 prkcaandprkcb psrrr ranked ranking resampling sparse tomm40 uses voxel wise
Tagcloud (Intersection) ?