PDPN and PRMT1

		PDPN	PRMT1
Description		podoplanin	protein arginine methyltransferase 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Cell Junction Filopodium Lamellipodium Membrane Cytoplasmic Vesicle Filopodium Membrane Microvillus Membrane Ruffle Membrane Cell Projection Membrane Raft Leading Edge Of Lamellipodium Anchoring Junction Tetraspanin-enriched Microdomain	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Methylosome
	Molecular Function	Signaling Receptor Binding Water Transmembrane Transporter Activity Protein Binding Folic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity Chemokine Binding Protein-folding Chaperone Binding	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone H4R3 Methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding GATOR1 Complex Binding Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Lymphangiogenesis Water Transport Amino Acid Transport Cell Adhesion Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Folic Acid Transport Cell Migration Platelet Activation Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Apoptotic Process Wound Healing, Spreading Of Cells Lymph Node Development Lymphatic Endothelial Cell Fate Commitment Actin-mediated Cell Contraction Positive Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Regulation Of Myofibroblast Contraction Regulation Of Lamellipodium Morphogenesis	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation DNA Damage Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of Translation Peptidyl-arginine Methylation Viral Protein Processing BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Neuron Projection Development Cellular Response To Nutrient Levels Methylation Cellular Response To Amino Acid Starvation TORC1 Signaling Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Negative Regulation Of JNK Cascade Positive Regulation Of Hemoglobin Biosynthetic Process Cardiac Muscle Tissue Development Protein Homooligomerization Cellular Response To Methionine Protein Localization To Lysosome Membraneless Organelle Assembly Positive Regulation Of P38MAPK Cascade Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		GPVI-mediated activation cascade Specification of primordial germ cells	RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS			Schizophrenia ( 29483656)
Interacting Genes		2 interacting genes: TMEM14B TOM1L1	165 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEBPA CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4C1 H4C14 H4C16 HABP4 HNF4A HNRNPA1 HNRNPA3 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MAP3K5 MBD2 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PPDPF PRMT8 QKI RBM15 RELA RNF187 RPL37A RPS29 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 SRSF1 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TK1 TOPORS TP53 TRIM48 TUBB UBE4B USP11 VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZCCHC12 ZMYM5 ZNF451
Entrez ID		10630	3276
HPRD ID		16398	04257
Ensembl ID		ENSG00000162493	ENSG00000126457
Uniprot IDs		Q86YL7	Q99873
PDB IDs		3WSR 4YO0 5XCV 7C94 7CQC 7CQD	6NT2
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Histone Methyltransferase Activity GATOR1 Complex Binding Cervix Development Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Metanephric Comma-shaped Body Morphogenesis Uterine Epithelium Development Positive Regulation Of Anterior Head Development Dorsal Spinal Cord Interneuron Posterior Axon Guidance Nephric Duct Elongation Ectoderm Formation Metanephric Glomerulus Development Metanephric Renal Vesicle Morphogenesis Renal Vesicle Morphogenesis Spinal Cord Interneuron Axon Guidance DNA-binding Transcription Factor Activity Regulation Of Hemoglobin Biosynthetic Process Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Methyltransferase Activity Cellular Response To Methionine Methylation Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Metanephric Part Of Ureteric Bud Development Pronephros Development Interneuron Axon Guidance Mesendoderm Development Oviduct Development Positive Regulation Of Gastrulation Lateral Motor Column Neuron Migration Oviduct Epithelium Development Anterior/posterior Axon Guidance Embryonic Retina Morphogenesis In Camera-type Eye Ureter Morphogenesis Spinal Cord Motor Neuron Migration S-shaped Body Morphogenesis Nephric Duct Development Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Comma-shaped Body Morphogenesis Mesonephric Duct Development Forebrain Regionalization Paramesonephric Duct Development Metanephric S-shaped Body Morphogenesis Histone H3K9 Trimethyltransferase Activity	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development MRNA Destabilization Negative Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Differentiation Negative Regulation Of Cytokine Production
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