PDPN and TOM1L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDPN	TOM1L1
Gene Name		podoplanin	target of myb1 (chicken)-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Lamellipodium Filopodium Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Water Transmembrane Transporter Activity Folic Acid Transporter Activity Amino Acid Transmembrane Transporter Activity Water Channel Activity	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Cell Morphogenesis Lymphangiogenesis Prostaglandin Metabolic Process Water Transport Amino Acid Transport Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Nervous System Development Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Platelet Activation Folic Acid Transport Single Organismal Cell-cell Adhesion Lung Development Positive Regulation Of Cell Migration Tube Morphogenesis Lung Alveolus Development Positive Regulation Of Cellular Component Movement Response To Hyperoxia Regulation Of G1/S Transition Of Mitotic Cell Cycle	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: TOM1L1	27 interactors: AMFR CCDC47 CELF1 COPS7A CWF19L1 FAM208A FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TOLLIP TSG101 TUBA1B UBXN4 VAV2 VCP
Entrez ID		10630	10040
HPRD ID		16398	05266
Ensembl ID		ENSG00000162493	ENSG00000141198
Uniprot IDs		Q86YL7	B7Z9E2 I3L4I4 O75674
PDB IDs			3RRU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Autophosphorylation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Protein Autophosphorylation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division	Phosphatidylinositol-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Endoplasmic Reticulum Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Neurotrophin TRK Receptor Signaling Pathway T Cell Costimulation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Organic Substance Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Fc Receptor Signaling Pathway ER-nucleus Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Wound Healing Response To Unfolded Protein Response To Stress Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Component Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Response To Wounding ER-associated Ubiquitin-dependent Protein Catabolic Process Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination NFAT Protein Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of ERBB Signaling Pathway Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation
Tagcloud ?		aggregation astrocytes cdk4 collectively concomitant cortex cortical great immunofluorescence injection knocking lateral lipopolysaccharide lps lungs lymphatic lymphoid mucin nervous neuroinflammation neuroinflammatory organs platelet podoplanin sialoglycoprotein sirna transmembrane ventral vessel	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Difference) ?		aggregation astrocytes cdk4 collectively concomitant cortex cortical great immunofluorescence injection knocking lateral lipopolysaccharide lps lungs lymphatic lymphoid mucin nervous neuroinflammation neuroinflammatory organs platelet podoplanin sialoglycoprotein sirna transmembrane ventral vessel	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Intersection) ?