IREB2 and OTUD3

Number of citations of the paper that reports this interaction (PubMedID 35490179)
42

Data Source:
BioGRID (pull down)

		IREB2	OTUD3
Description		iron responsive element binding protein 2	OTU deubiquitinase 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Translation Protoporphyrinogen IX Biosynthetic Process Intracellular Iron Ion Homeostasis Post-embryonic Development Regulation Of Gene Expression Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis MRNA Stabilization Intestinal Absorption Multicellular Organismal-level Iron Ion Homeostasis	Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Deubiquitination Cellular Response To Nutrient Levels Ribosome Disassembly Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein K48-linked Deubiquitination Rescue Of Stalled Ribosome Energy Homeostasis Protein K27-linked Deubiquitination
Pathways		Iron uptake and transport	Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 20173748 25241909) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 29483656 25056061)	Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19122664 19915572 20228798 20228799 23511034 28067908)
Interacting Genes		6 interacting genes: APP OTUD3 RBCK1 TERT USP53 YBX1	17 interacting genes: ATG14 BGLT3 BHLHE22 CGAS FOXA2 FOXN1 HNF1B HOXB8 HSD17B14 HSPA5 IREB2 PPARD SIX3 STUB1 TP53 UBC UBE2L3
Entrez ID		3658	23252
HPRD ID		08858	19417
Ensembl ID		ENSG00000136381	ENSG00000169914
Uniprot IDs		P48200	Q5T2D3
PDB IDs		6VCD	4BOU
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Auditory Stimulus Negative Regulation Of Cellular Senescence Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Senescence TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Cysteine-type Deubiquitinase Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization MiRNA Transport RNA-directed RNA Polymerase Activity RNA-templated Transcription Positive Regulation Of Hair Cycle RNA-directed DNA Polymerase Activity Telomerase Catalytic Core Complex Protein K6-linked Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Outer Hair Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Cellular Response To Glucose Starvation Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process ER Overload Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Senescence Endocrine Pancreas Development Cellular Response To Nutrient Levels Misfolded Protein Binding Transcription Cis-regulatory Region Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Protein-folding Chaperone Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Gene Expression Intracellular Signaling Cassette Circadian Behavior Regulation Of Macromolecule Biosynthetic Process Rhythmic Behavior Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Negative Regulation Of RNA Metabolic Process Cellular Response To Decreased Oxygen Levels T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Catabolic Process Apoptotic Process Involved In Development Determination Of Adult Lifespan
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