TRIM65 and TNRC6A

Number of citations of the paper that reports this interaction (PubMedID 24778252)
45

Data Source:
BioGRID (enzymatic study)

		TRIM65	TNRC6A
Description		tripartite motif containing 65	trinucleotide repeat containing adaptor 6A
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	P-body Nucleoplasm Cytoplasm Golgi Apparatus Cytosol RISC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding RNA Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Immune System Process Inflammatory Response Positive Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Protein Oligomerization Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Inflammatory Response Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Regulation Of Translation Endoderm Development Cellular Response To Starvation Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways			Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS		Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 30002152 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418 27618448 27841878) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 RIGI SRPK1 TNRC6A TP53 UBE2D2 UBE2N UBE2U UBE2Z UBE3A VCAM1	10 interacting genes: DMRTB1 PAN2 QKI RBFOX2 SMARCB1 TRIM65 TRIP13 TXNL4A UBC WNK1
Entrez ID		201292	27327
HPRD ID		15569	11640
Ensembl ID		ENSG00000141569	ENSG00000090905
Uniprot IDs		Q6PJ69	Q8NDV7
PDB IDs		7JL0 7JL2 7JL4	5W6V 7RUP
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Metabolic Process Transferase Activity Macromolecule Metabolic Process Detection Of Virus Regulation Of Type III Interferon Production Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process MRNA Transcription Protein Autoubiquitination Proteolysis Proteasomal Protein Catabolic Process Antiviral Innate Immune Response Response To Nutrient Levels MDM2/MDM4 Family Protein Binding Cellular Response To Nutrient Levels Catabolic Process Zinc Ion Binding ATP Binding Cellular Response To Exogenous DsRNA Ubiquitin Binding Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Polyubiquitination Protein Catabolic Process Cytosol Cellular Response To DsRNA Positive Regulation Of Post-translational Protein Modification Immune Response-activating Signaling Pathway Positive Regulation Of Interferon-alpha Production Regulation Of Protein Polyubiquitination Nucleotide Binding Immune Response-regulating Signaling Pathway Response To Stress Activation Of Immune Response Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Programmed Necrotic Cell Death Response To External Biotic Stimulus Immune System Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	RNA Metabolic Process Macromolecule Metabolic Process MRNA Processing
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