PAIP1 and EIF3A

Number of citations of the paper that reports this interaction (PubMedID 24396066)
38

Data Source:
BioGRID (pull down)

		PAIP1	EIF3A
Description		poly(A) binding protein interacting protein 1	eukaryotic translation initiation factor 3 subunit A
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GO Annotations	Cellular Component	Cytoplasm Cytosol MCRD-mediated MRNA Stability Complex	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Organelle Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Host-mediated Activation Of Viral Process MRNA Stabilization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		Deadenylation of mRNA Deadenylation of mRNA M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		10 interacting genes: EIF3A EIF3B EIF4A1 MYB OGT PABPC1 RND1 TMEM132D UBR5 WWP2	26 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF10 RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 WEE2-AS1 YWHAZ
Entrez ID		10605	8661
HPRD ID		05539	03618
Ensembl ID		ENSG00000172239	ENSG00000107581
Uniprot IDs		Q9H074	Q14152
PDB IDs		1JH4 3NTW 3RK6 6YXJ	3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translational Initiation Cytoplasmic Stress Granule IRES-dependent Viral Translational Initiation Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol MRNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Biosynthetic Process RNA Binding Positive Regulation Of Hepatic Stellate Cell Proliferation Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Heterochromatin Boundary Formation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Testosterone Secretion Regulation Of Translational Initiation Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Translation Reinitiation Multi-eIF Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of RNA Metabolic Process Cytoplasm Protein Quality Control Vitamin D Receptor Signaling Pathway	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Regulation Of Translational Initiation Eukaryotic 43S Preinitiation Complex Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression RNA Binding Translation Eukaryotic Translation Initiation Factor 4F Complex RNA Strand Annealing Activity Viral Translational Termination-reinitiation BBSome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cytosol TORC1 Signaling Protein-containing Complex Organization Hippocampus Development Cytoplasm Striatum Development Negative Regulation Of Catabolic Process Regulation Of Cilium Beat Frequency Cerebral Cortex Development Regulation Of Protein Metabolic Process TOR Signaling Retina Homeostasis Protein-containing Complex Assembly Cytoplasmic Stress Granule Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Component Assembly Ventricular System Development Brain Morphogenesis Translation Factor Activity, RNA Binding Regulation Of TORC1 Signaling Translation Initiation Factor Binding Protein Metabolic Process Negative Regulation Of Autophagy Regulation Of Circadian Sleep/wake Cycle Regulation Of Biological Quality Tube Formation Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cilium Movement Adult Behavior Regulation Of Macromolecule Biosynthetic Process
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