PAIP1 and EIF3B

Number of citations of the paper that reports this interaction (PubMedID 24396066)
38

Data Source:
BioGRID (pull down)

		PAIP1	EIF3B
Description		poly(A) binding protein interacting protein 1	eukaryotic translation initiation factor 3 subunit B
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GO Annotations	Cellular Component	Cytoplasm Cytosol MCRD-mediated MRNA Stability Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Host-mediated Activation Of Viral Process MRNA Stabilization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		Deadenylation of mRNA Deadenylation of mRNA M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		10 interacting genes: EIF3A EIF3B EIF4A1 MYB OGT PABPC1 RND1 TMEM132D UBR5 WWP2	18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1
Entrez ID		10605	8662
HPRD ID		05539	06795
Ensembl ID		ENSG00000172239	ENSG00000106263
Uniprot IDs		Q9H074	P55884
PDB IDs		1JH4 3NTW 3RK6 6YXJ	2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translational Initiation Cytoplasmic Stress Granule IRES-dependent Viral Translational Initiation Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol MRNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Biosynthetic Process RNA Binding Positive Regulation Of Hepatic Stellate Cell Proliferation Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Heterochromatin Boundary Formation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Testosterone Secretion Regulation Of Translational Initiation Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Translation Reinitiation Multi-eIF Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of RNA Metabolic Process Cytoplasm Protein Quality Control Vitamin D Receptor Signaling Pathway	Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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