PAIP1 and PABPC1

Number of citations of the paper that reports this interaction (PubMedID 33876849)
84

Data Source:
BioGRID (pull down, cross-linking study, affinity chromatography technology)
HPRD (in vitro, in vivo)

		PAIP1	PABPC1
Description		poly(A) binding protein interacting protein 1	poly(A) binding protein cytoplasmic 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol MCRD-mediated MRNA Stability Complex	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity
	Biological Process	Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Host-mediated Activation Of Viral Process MRNA Stabilization CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Deadenylation of mRNA Deadenylation of mRNA M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: EIF3A EIF3B EIF4A1 MYB OGT PABPC1 RND1 TMEM132D UBR5 WWP2	55 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 MAPKAPK2 MKRN1 NDRG1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG
Entrez ID		10605	26986
HPRD ID		05539	05247
Ensembl ID		ENSG00000172239	ENSG00000070756
Uniprot IDs		Q9H074	P11940
PDB IDs		1JH4 3NTW 3RK6 6YXJ	1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translational Initiation Cytoplasmic Stress Granule IRES-dependent Viral Translational Initiation Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol MRNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Biosynthetic Process RNA Binding Positive Regulation Of Hepatic Stellate Cell Proliferation Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Heterochromatin Boundary Formation Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Testosterone Secretion Regulation Of Translational Initiation Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Translation Reinitiation Multi-eIF Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of RNA Metabolic Process Cytoplasm Protein Quality Control Vitamin D Receptor Signaling Pathway	Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly
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