GTF2B and NR1D2

Number of citations of the paper that reports this interaction (PubMedID 9611234)
39

Data Source:
BioGRID (pull down)

		GTF2B	NR1D2
Description		general transcription factor IIB	nuclear receptor subfamily 1 group D member 2
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Nucleus Nucleoplasm Transcription Factor TFIID Complex Chromosome Nuclear Body Cell Division Site Protein-DNA Complex Germinal Vesicle RNA Polymerase II Transcription Regulator Complex Transcription Preinitiation Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA Binding Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity TBP-class Protein Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcriptional Start Site Selection At RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Acetylation Gene Expression Viral Transcription RNA Polymerase II Preinitiation Complex Assembly Meiotic Sister Chromatid Cohesion Spindle Assembly Chromosome Organization Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding RNA Polymerase II Core Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Circadian Behavior Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Lipid Homeostasis Energy Homeostasis Regulation Of Skeletal Muscle Cell Differentiation
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Nuclear Receptor transcription pathway
Drugs			SR-9009 SR-9011
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Hematocrit ( 32888494) Intraocular pressure ( 29617998) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 28135244 30578418)	Acne (severe) ( 24927181) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Asthma ( 29273806) Cognitive ability ( 29186694) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278)
Interacting Genes		56 interacting genes: ADRB2 ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GOLGA6L9 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE	54 interacting genes: CRY1 CSNK1E CSNK2A2 CUL1 CYSRT1 DELEC1 EFEMP2 GTF2B HDAC1 HOXA1 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS8 MEOX2 MID2 MYLIP MYO15B NBPF19 NCOA5 NCOR1 NOTCH2NLA NR1D1 PCSK5 PRMT6 PROP1 RBPMS RGN RORC SIN3B TAF6 TAF9 TBC1D21 TENT5B TRIM27 TRIM55 TRIM63 TRIP6 TTC3 UBE2I ZNF587
Entrez ID		2959	9975
HPRD ID		08928	03809
Ensembl ID		ENSG00000137947	ENSG00000174738
Uniprot IDs		Q00403	B4DXD3 F1D8P2 Q14995
PDB IDs		1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5WH1 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2V0V 2V7C 3CQV 4N73 6WMQ 6WMS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Macromolecule Metabolic Process Nucleus Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Regulation Of Metabolic Process Nuclear Receptor Activity Transcription Factor TFIID Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Metabolic Process MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity	Intermediate Filament Keratin Filament Circadian Regulation Of Gene Expression Circadian Rhythm Negative Regulation Of Catabolic Process Nuclear Thyroid Hormone Receptor Binding Rhythmic Process Transcription Factor TFIID Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Circadian Rhythm RNA Polymerase II Preinitiation Complex Assembly Cytosol
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