GTF2B and FOXF2

Number of citations of the paper that reports this interaction (PubMedID 9722567)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GTF2B	FOXF2
Description		general transcription factor IIB	forkhead box F2
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Nucleus Nucleoplasm Transcription Factor TFIID Complex Chromosome Nuclear Body Cell Division Site Protein-DNA Complex Germinal Vesicle RNA Polymerase II Transcription Regulator Complex Transcription Preinitiation Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Body
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA Binding Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity TBP-class Protein Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding Protein-lysine-acetyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding General Transcription Initiation Factor Binding
	Biological Process	Transcriptional Start Site Selection At RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Acetylation Gene Expression Viral Transcription RNA Polymerase II Preinitiation Complex Assembly Meiotic Sister Chromatid Cohesion Spindle Assembly Chromosome Organization Transcription Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding RNA Polymerase II Core Complex Assembly	Epithelial To Mesenchymal Transition Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Planar Polarity Of Embryonic Epithelium Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Embryonic Camera-type Eye Morphogenesis System Development Genitalia Development Roof Of Mouth Development Regulation Of Protein Polyubiquitination
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Hematocrit ( 32888494) Intraocular pressure ( 29617998) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 28135244 30578418)	Anti-thyroid drug induced agranulocytosis ( 27157822) Bladder cancer (smoking interaction) ( 24662972) Daytime sleep phenotypes ( 27126917) Erectile dysfunction ( 30583798) Glaucoma (primary open-angle) ( 33627673) Hepcidin/ferritin ratio ( 27846281) Intraocular pressure ( 29235454 29617998) Metabolite levels ( 23823483) Non-response to citalopram or escitalopram and depression ( 27622933) Stroke ( 27068588) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		56 interacting genes: ADRB2 ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GOLGA6L9 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE	2 interacting genes: GTF2B TBP
Entrez ID		2959	2295
HPRD ID		08928	09131
Ensembl ID		ENSG00000137947	ENSG00000137273
Uniprot IDs		Q00403	Q12947
PDB IDs		1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5WH1 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWC 7ZWD 7ZX7 7ZX8 7ZXE 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Macromolecule Metabolic Process Nucleus Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription By RNA Polymerase II Regulation Of Metabolic Process Nuclear Receptor Activity Transcription Factor TFIID Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Metabolic Process MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity RNA Polymerase II Preinitiation Complex Assembly Transcription Initiation At RNA Polymerase II Promoter Transcription Preinitiation Complex Assembly DNA-templated Transcription Initiation Transcriptional Start Site Selection At RNA Polymerase II Promoter Protein-DNA Complex Assembly DNA-binding Transcription Factor Binding RNA Polymerase II Core Complex Assembly Transcription By RNA Polymerase II Positive Regulation Of Core Promoter Binding Germinal Vesicle TFIIB-class Transcription Factor Binding RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex DNA-templated Transcription Viral Transcription RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Male Pronucleus Aryl Hydrocarbon Receptor Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Meiotic Sister Chromatid Cohesion Positive Regulation Of Transcription Regulatory Region DNA Binding RNA Polymerase III General Transcription Initiation Factor Activity Transcription Preinitiation Complex Female Germ Cell Nucleus Cell Division Site Core Promoter Sequence-specific DNA Binding Acetyltransferase Activity Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of DNA Binding Nucleobase-containing Compound Biosynthetic Process Protein-lysine-acetyltransferase Activity TBP-class Protein Binding Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II Complex Binding Histone Acetyltransferase Activity Protein Acetylation Transcription By RNA Polymerase III Condensed Chromosome Sister Chromatid Cohesion Protein-DNA Complex Protein-containing Complex Assembly Regulation Of DNA Binding Positive Regulation Of Binding
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