FLOT1 and FLOT2

Number of citations of the paper that reports this interaction (PubMedID 17113085)
0

Data Source:
HPRD (in vitro)

		FLOT1	FLOT2
Description		flotillin 1	flotillin 2
Image
GO Annotations	Cellular Component	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse	Uropod Acrosomal Membrane Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Dendrite Cytoplasm Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Protease Binding Protein Binding
	Biological Process	Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Protein Localization To Plasma Membrane Anterograde Dendritic Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)	Declining hemoglobin trajectory in blood donors ( 33491795) Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)
Interacting Genes		26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL	12 interacting genes: ANXA1 APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC
Entrez ID		10211	2319
HPRD ID		06105	00580
Ensembl ID		ENSG00000137312	ENSG00000132589
Uniprot IDs		O75955 Q5ST80	J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs		9BQ2	9BQ2
Enriched GO Terms of Interacting Partners?		Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding	Caveola Assembly Plasma Membrane Raft Assembly Membrane Raft Assembly Plasma Membrane Raft Organization Membrane Raft Caveolar Macromolecular Signaling Complex Membrane Raft Organization Growth Factor Receptor Binding Endosome Early Endosome Membrane Endocytosis Membrane Assembly Peptidase Activator Activity Caveola Regulation Of Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Receptor-mediated Endocytosis Of Virus By Host Cell Cellular Response To Growth Factor Stimulus Regulation Of Dendritic Spine Maintenance Import Into Cell Endocytosis Involved In Viral Entry Into Host Cell Response To Growth Factor Early Endosome Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Neurotransmitter Uptake Regulation Of Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Signaling Receptor Binding Positive Regulation Of Cell Activation G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Acrosomal Membrane Focal Adhesion Positive Regulation Of Transport Cytoplasmic Vesicle Regulation Of Extrinsic Apoptotic Signaling Pathway Ephrin Receptor Binding Negative Regulation Of Receptor Signaling Pathway Via STAT Receptor-mediated Endocytosis Basement Membrane Organization Negative Regulation Of Macromolecule Biosynthetic Process Plasma Membrane Raft Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Negative Regulation Of Biosynthetic Process Endothelial Cell Proliferation Regulation Of Cell-cell Adhesion
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