FLOT1 and FLOT2

Number of citations of the paper that reports this interaction (PMID 17113085)
3

Data Source:
HPRD (in vitro)

		FLOT1	FLOT2
Gene Name		flotillin 1	flotillin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Microtubule Organizing Center Caveola Focal Adhesion COP9 Signalosome Membrane Integral Component Of Membrane Flotillin Complex Centriolar Satellite Sarcolemma Melanosome Membrane Raft Extracellular Vesicular Exosome	Acrosomal Membrane Endosome Plasma Membrane Caveola Focal Adhesion Membrane Flotillin Complex Endocytic Vesicle Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Axonogenesis Extracellular Matrix Disassembly Regulation Of Rho Protein Signal Transduction Establishment Of Protein Localization To Plasma Membrane	Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Protein Stabilization Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Ulcerative colitis ( 20848476)
Protein-Protein Interactions		16 interactors: APP ARG1 AURKB CAPN10 CBL FLOT2 FYN GOLM1 INCENP NGB PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1	8 interactors: APP CAV1 CAV2 DXO FLOT1 FYN NMNAT1 SPATA24
Entrez ID		10211	2319
HPRD ID		06105	00580
Ensembl ID		ENSG00000137312	ENSG00000132589
Uniprot IDs		B4DVY7 O75955 Q5ST80	J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Adhesion Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Positive Regulation Of Cell Cycle Process Organelle Organization Positive Regulation Of Glucose Import Chromosome Segregation Cellular Response To Hormone Stimulus Positive Regulation Of Glucose Transport Actin Cytoskeleton Organization Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament-based Process Regulation Of L-arginine Import Primary Spermatocyte Growth Positive Regulation Of Cell Cycle Regulation Of Glucose Import Actin Filament Organization Positive Regulation Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of ERBB Signaling Pathway Synaptic Growth At Neuromuscular Junction Type B Pancreatic Cell Apoptotic Process Developmental Cell Growth Response To Organonitrogen Compound Regulation Of Apoptotic Process Feeding Behavior Regulation Of Glucose Transport Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Spindle Stabilization Response To Hormone Nucleus Organization Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cell Death Dendrite Development	Caveola Assembly Membrane Raft Assembly Membrane Raft Organization Membrane Assembly Membrane Biogenesis Plasma Membrane Organization Negative Regulation Of Endothelial Cell Proliferation Regulation Of Protein Tyrosine Kinase Activity Cell Differentiation T Cell Costimulation Blood Coagulation Hemostasis Endomembrane System Organization Regulation Of Endothelial Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Water-soluble Vitamin Metabolic Process Feeding Behavior Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axonogenesis Vitamin Metabolic Process Synaptic Growth At Neuromuscular Junction Nitric Oxide Homeostasis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Body Fluid Levels Vesicle-mediated Transport Negative Regulation Of Epithelial Cell Proliferation Wound Healing Dendrite Development Regulation Of Signal Transduction Skeletal Muscle Tissue Development Learning Neuron Projection Morphogenesis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Dopamine Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Skeletal Muscle Organ Development Endocytosis Protein Localization To Plasma Membrane Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Response To Wounding Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis
Tagcloud ?		anchorage archived caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc flot2 hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital	adjacent aimed archived biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated
Tagcloud (Difference) ?		anchorage caveolin chicken chorioallantoic constitutive downregulation electrophoretic escc esccs esophageal essc hyperactivation intermediaries inverse inversely k63 luciferase mir polyubiquitination raft rafts rip1 suppressive traf2 transwell upregulating vital	adjacent aimed biomarker biopsies blotting breast classification clinicopathological duration embedded erbb2 flotillin histological ihc immunohistochemistry implicated multivariate noncancerous paired paraffin prognostic quantified real shorter significance statistical tissues upregulated
Tagcloud (Intersection) ?		archived flot2