FLOT1 and INCENP

Number of citations of the paper that reports this interaction (PubMedID 20430883)
31

Data Source:
BioGRID (pull down)

		FLOT1	INCENP
Description		flotillin 1	inner centromere protein
Image
GO Annotations	Cellular Component	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse	Chromosome, Centromeric Region Kinetochore Synaptonemal Complex Lateral Element Central Element Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Chromocenter Microtubule Cytoskeleton Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Protein Binding Molecular Function Activator Activity
	Biological Process	Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Mitotic Cell Cycle Mitotic Cytokinesis Chromosome Segregation Mitotic Spindle Midzone Assembly Meiotic Spindle Midzone Assembly Cell Division Metaphase Chromosome Alignment Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			Reversine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)	Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Major depressive disorder x sex interaction ( 34099189) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL	10 interacting genes: AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14 PIN1
Entrez ID		10211	3619
HPRD ID		06105	05103
Ensembl ID		ENSG00000137312	ENSG00000149503
Uniprot IDs		O75955 Q5ST80	Q9NQS7
PDB IDs		9BQ2	2QFA 4AF3 5IEH 5IEK 6GR8 6GR9 6YIE 6YIF 6YIH 8RUP 9ESA
Enriched GO Terms of Interacting Partners?		Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding	Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Spindle Midzone Assembly Regulation Of Cytokinesis Spindle Midzone Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Cytokinesis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome, Centromeric Region Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Chromocenter Regulation Of Cell Division Positive Regulation Of Mitotic Cytokinesis Midbody Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Checkpoint Spindle Positive Regulation Of Cell Division Mitotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Nuclear Division Positive Regulation Of Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Separation Regulation Of Nuclear Division Spindle Microtubule Spindle Organization Mitotic Spindle Assembly Kinetochore Microtubule-based Process Cell Division Regulation Of Mitotic Sister Chromatid Separation Mitotic Cytokinesis Cytoskeleton Organization Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Process Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Regulation Of Organelle Organization Regulation Of Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation
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