FLOT1 and PSMD4

Number of citations of the paper that reports this interaction (PubMedID 18164080)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		FLOT1	PSMD4
Description		flotillin 1	proteasome 26S subunit ubiquitin receptor, non-ATPase 4
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GO Annotations	Cellular Component	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Plasma Membrane Raft Membrane Raft Synapse Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	RNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Receptor Internalization Axonogenesis Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Positive Regulation Of Synaptic Transmission, Dopaminergic Adherens Junction Organization Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Plasma Membrane Raft Organization Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Neurotransmitter Uptake Caveola Assembly Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Hip circumference adjusted for BMI ( 34021172) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ANXA1 APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 RSPH1 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC VHL	46 interacting genes: ADRM1 APP BTRC CCNA2 CFTR CUL1 EGFR FBXO25 FLOT1 GNB5 H2AC4 H2BC3 ID1 MAP3K1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 OGT PRKN PTEN RAD23A RAD23B RASSF8 RBCK1 RBM11 SCHIP1 SIAH2 SMURF1 SREBF2 STUB1 TCF3 TCP11L1 TMEM129 TP53 TRIM63 UBB UBC UBD UBE2C UBQLN1 UBQLN2 WWP2 XPC
Entrez ID		10211	5710
HPRD ID		06105	03386
Ensembl ID		ENSG00000137312	ENSG00000159352
Uniprot IDs		O75955 Q5ST80	P55036 Q5VWC4
PDB IDs		9BQ2	1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6MUN 6U19 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Flotillin Complex Protein Serine/threonine Kinase Binding Ephrin Receptor Binding Membrane Raft Growth Factor Receptor Binding Chromosome Passenger Complex Focal Adhesion Cell-substrate Junction Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Cytosol Regulation Of Dendritic Spine Maintenance Positive Regulation Of Mitotic Cytokinesis Spindle Midzone Assembly Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromocenter Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Negative Regulation Of Type 2 Immune Response Negative Regulation Of Immune Response Positive Regulation Of Cell Cycle Checkpoint Cytoplasm Insulin Receptor Binding Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytoskeleton Organization Response To Platelet-derived Growth Factor Molecular Function Activator Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Growth Factor Stimulus Regulation Of Cell Communication Regulation Of Signaling Amyloid Fibril Formation Positive Regulation Of Chromosome Segregation Response To Growth Factor Protein Binding Regulation Of Programmed Cell Death Regulation Of Type 2 Immune Response Positive Regulation Of Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Macromolecule Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis Protein Catabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Proteasome Binding Cytoplasm Cellular Response To Stress Protein-folding Chaperone Binding Ubiquitin Binding Regulation Of Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Ubiquitin Ligase Complex Regulation Of Signal Transduction Protein Destabilization
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