ARFGEF1 and ARFGEF2

Number of citations of the paper that reports this interaction (PMID 10716990)
37

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		ARFGEF1	ARFGEF2
Gene Name		ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding ARF GTPase Activator Activity Myosin Binding Protein Kinase A Regulatory Subunit Binding	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Negative Regulation Of Actin Filament Polymerization Regulation Of ARF Protein Signal Transduction Negative Regulation Of Rho GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Glycosylation In Golgi Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways			Protein folding Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ARFGEF2 DPY30 FKBP2 MYO9B	9 interactors: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		10565	10564
HPRD ID		09163	09250
Ensembl ID		ENSG00000066777	ENSG00000124198
Uniprot IDs		Q9Y6D6	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		3LTL	3L8N 3SWV
Enriched GO Terms of Interacting Partners?			Cellular Response To Histamine Response To Histamine Cellular Response To Ammonium Ion Cellular Response To Organonitrogen Compound Negative Regulation Of CAMP-dependent Protein Kinase Activity Response To Ammonium Ion Response To Organonitrogen Compound Chloride Transmembrane Transport Regulation Of CAMP-dependent Protein Kinase Activity Activation Of Protein Kinase A Activity Chloride Transport Renal Water Homeostasis Innervation Cellular Response To Glucagon Stimulus Inner Ear Receptor Cell Development Inorganic Anion Transport Water Transport Fluid Transport Cochlea Development Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Transmembrane Transport Inner Ear Receptor Cell Differentiation Water Homeostasis Mechanoreceptor Differentiation Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Phospholipase Activity Anion Transmembrane Transport Positive Regulation Of Protein Glycosylation In Golgi Transport Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Nerve Development Renal System Process Synaptic Transmission Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Organic Substance Energy Reserve Metabolic Process Positive Regulation Of Protein Glycosylation Sensory Perception Of Sound Anion Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Acylglycerol Acyl-chain Remodeling Negative Regulation Of Neuron Apoptotic Process Sensory Perception Of Mechanical Stimulus
Tagcloud ?			13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Difference) ?			13q33 15q26 20q13 22q11 already c20orf199 candidate chromosomes copy cse1l ddx27 deficiency duplications gh hemizygous homozygous individuals integrin investigations itgbl1 kcnb1 mb oligonucleotide predispose ptgis remaining snord12 unreported znfx1
Tagcloud (Intersection) ?