ARFGEF1 and FKBP2

Number of citations of the paper that reports this interaction (PMID 12606707)
14

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ARFGEF1	FKBP2
Gene Name		ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	FK506 binding protein 2, 13kDa
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding ARF GTPase Activator Activity Myosin Binding Protein Kinase A Regulatory Subunit Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding
	Biological Process	Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Negative Regulation Of Actin Filament Polymerization Regulation Of ARF Protein Signal Transduction Negative Regulation Of Rho GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Glycosylation In Golgi Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity	Protein Peptidyl-prolyl Isomerization Chaperone-mediated Protein Folding
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ARFGEF2 DPY30 FKBP2 MYO9B	13 interactors: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN4 VAMP2
Entrez ID		10565	2286
HPRD ID		09163	01742
Ensembl ID		ENSG00000066777	ENSG00000173486
Uniprot IDs		Q9Y6D6	P26885 Q53XJ5
PDB IDs		3LTL	2PBC
Enriched GO Terms of Interacting Partners?			Ras Protein Signal Transduction Cortical Actin Cytoskeleton Organization Regulation Of Protein Metabolic Process Establishment Of Protein Localization Endomembrane System Organization Cortical Cytoskeleton Organization Small GTPase Mediated Signal Transduction Protein Localization Regulation Of Cellular Protein Metabolic Process Synaptic Vesicle Exocytosis Rab Protein Signal Transduction Cellular Protein Localization Immune System Process Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Protein Glycosylation In Golgi Vesicle-mediated Transport Exocytosis Protein Localization To Membrane Cellular Localization Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Intracellular Transport Neurotransmitter Secretion Synaptic Vesicle Transport Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Eosinophil Degranulation Regulation Of Cellular Localization Intracellular Signal Transduction Regulation Of Golgi Inheritance Positive Regulation Of Protein Glycosylation Secretion By Cell Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Neurotransmitter Levels Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Regulation Of Protein Binding Protein Localization To Plasma Membrane Regulation Of Exocytosis Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Protein Export From Nucleus Neurotransmitter Transport Actin Cytoskeleton Organization Organelle Organization Regulation Of Golgi Organization Protein K6-linked Ubiquitination Negative Regulation Of Granulocyte Differentiation
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