ARFGEF1 and FKBP2

Number of citations of the paper that reports this interaction (PubMedID 12606707)
34

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ARFGEF1	FKBP2
Description		ARF guanine nucleotide exchange factor 1	FKBP prolyl isomerase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Isomerase Activity
	Biological Process	Protein Glycosylation Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity
Pathways
Drugs
Diseases
GWAS		Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)	Bipolar disorder ( 34002096) Crohn's disease ( 28067908) Fruit consumption ( 32066663)
Interacting Genes		5 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 MYO9B	14 interacting genes: ARFGEF1 BAG6 BARD1 C1QC EPB41 EPB41L2 MAPK3 RAB3C RAB6A RAP2A UBQLN1 UBQLN2 UBQLN4 VAMP2
Entrez ID		10565	2286
HPRD ID		09163	01742
Ensembl ID		ENSG00000066777	ENSG00000173486
Uniprot IDs		Q9Y6D6	A0A494C1N0 P26885 Q53XJ5
PDB IDs		3LTL 5EE5 5J5C	2PBC 4NNR
Enriched GO Terms of Interacting Partners?		Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Hemopoiesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Timing Of Anagen Lamellipodium Fungiform Papilla Formation Negative Regulation Of Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transmembrane Transporter Binding Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Perinuclear Region Of Cytoplasm Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Hemopoiesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cell Cortex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Adherens Junction Renal Outer Medulla Development Regulation Of Myeloid Leukocyte Differentiation Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cell Morphogenesis Positive Regulation Of Branching Involved In Lung Morphogenesis	Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway Regulation Of Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Cell Cortex Autophagosome Organelle Organization Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Catabolic Process Myosin V Binding Autophagosome Organization Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Cytosol Regulation Of Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Spectrin Binding Regulation Of Autophagy Perinuclear Region Of Cytoplasm Cortical Actin Cytoskeleton Organization Negative Regulation Of Transport Vacuole Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization Trans-Golgi Network Cytoplasmic Vesicle Exocytosis Positive Regulation Of Proteolysis Cortical Cytoskeleton Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MRNA 3'-end Processing Peptidyl-cysteine Methylation Negative Regulation Of Store-operated Calcium Channel Activity Response To Endoplasmic Reticulum Stress Regulation Of Vesicle-mediated Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process
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