ARFGEF1

Description		ARF guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Protein Glycosylation Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity
Pathways
Drugs
Diseases
GWAS		Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)
Novel Interacting Genes		1 novel interacting genes: LYN
Interacting Genes		5 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 MYO9B
Entrez ID		10565
HPRD ID		09163
Ensembl ID		ENSG00000066777
Uniprot IDs		Q9Y6D6
PDB IDs		3LTL 5EE5 5J5C
Enriched GO Terms of Interacting Partners?		Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Hemopoiesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Timing Of Anagen Lamellipodium Fungiform Papilla Formation Negative Regulation Of Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transmembrane Transporter Binding Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Perinuclear Region Of Cytoplasm Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Hemopoiesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cell Cortex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Adherens Junction Renal Outer Medulla Development Regulation Of Myeloid Leukocyte Differentiation Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cell Morphogenesis Positive Regulation Of Branching Involved In Lung Morphogenesis
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