BHMT and BBS2

Number of citations: 0 (PubMedID 18000879)
Data Source: BioGRID (two hybrid)

		BHMT	BBS2
Name		betaine--homocysteine S-methyltransferase	Bardet-Biedl syndrome 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Sulfur amino acid metabolism Choline catabolism	BBSome-mediated cargo-targeting to cilium
Drugs		Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine	None
Diseases		None	Bardet-Biedl syndrome (BBS)
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151 ) Blood and toenail selenium levels ( 25343990 ) Blood trace element (Se levels) ( 23720494 ) Metabolite levels ( 23378610 23823483 ) Serum metabolite levels ( 33031748 ) Toenail selenium levels ( 25343990 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC
Entrez ID		635	583
HPRD ID		04200	05855
Ensembl ID		ENSG00000145692	ENSG00000125124
Uniprot IDs		Q93088 V9HWA4	A0A804HIE1 A0A804HKG1 Q9BXC9
PDB IDs		1LT7 1LT8 4M3P 8D45	Not available
GO Terms Enriched among Interactors		BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling	Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center