BHMT and BBS2

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		BHMT	BBS2
Gene Name		betaine--homocysteine S-methyltransferase	Bardet-Biedl syndrome 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome	Cytosol Motile Cilium BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Zinc Ion Binding S-adenosylmethionine-homocysteine S-methyltransferase Activity Protein Complex Binding Betaine-homocysteine S-methyltransferase Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Response To Organonitrogen Compound S-methylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	Organelle Organization Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Nonmotile Primary Cilium Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Pathways		Sulfur amino acid metabolism Metabolism of amino acids and derivatives	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs		L-Methionine S-(D-Carboxybutyl)-L-Homocysteine Citric Acid
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610)
Protein-Protein Interactions		5 interactors: ALG9 BBS1 BBS2 BBS4 LAMTOR3	11 interactors: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 HSCB KRT18 MDFI PAX2 PSME3 RBPMS
Entrez ID		635	583
HPRD ID		04200	05855
Ensembl ID		ENSG00000145692	ENSG00000125124
Uniprot IDs		E5RJH0 Q93088	Q9BXC9
PDB IDs		1LT7 1LT8
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Photoreceptor Cell Maintenance Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Cellular Response To Leptin Stimulus Regulation Of Microtubule-based Movement Cilium Assembly Striatum Development Response To Leptin Visual Perception Sensory Perception Of Light Stimulus Tissue Homeostasis Cilium Organization Regulation Of Response To Food Cilium Morphogenesis Regulation Of Appetite Subpallium Development Golgi To Plasma Membrane Protein Transport Multicellular Organismal Homeostasis Cell Projection Assembly Golgi To Plasma Membrane Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Brain Morphogenesis Positive Regulation Of Multicellular Organism Growth Cellular Protein Localization Cellular Pigmentation Organelle Assembly Hippocampus Development Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Limbic System Development Regulation Of Multicellular Organism Growth Protein Localization Pigmentation Fat Cell Differentiation Spermatid Development Sensory Perception Spermatid Differentiation Protein Localization To Plasma Membrane Cell Projection Morphogenesis Positive Regulation Of Developmental Growth Cerebral Cortex Development Cell Part Morphogenesis	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Golgi To Plasma Membrane CFTR Protein Transport Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Embryonic Organ Development Embryonic Placenta Development Amino-acid Betaine Catabolic Process Regulation Of Homocysteine Metabolic Process Negative Regulation Of Cytolysis Kidney Rudiment Formation Paramesonephric Duct Development Vestibulocochlear Nerve Formation Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Regulation Of Kidney Size Positive Regulation Of Metabolic Process Positive Regulation Of Metanephric Glomerulus Development Nephric Duct Formation Metanephric Mesenchymal Cell Differentiation Ureter Morphogenesis Metanephric Tubule Formation Ureter Maturation Regulation Of Protein Import Into Nucleus Visual Perception Sensory Perception Of Light Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Mesodermal Cell Fate Specification Myoblast Fate Commitment Placenta Development Negative Regulation Of Wnt Signaling Pathway Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Regulation Of Protein Localization To Nucleus Cellular Response To Oxidative Stress Cellular Response To Stress Developmental Process Involved In Reproduction Optic Cup Morphogenesis Involved In Camera-type Eye Development
Tagcloud ?		1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike	actr1a backgrounds bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike	actr1a backgrounds bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?