BHMT

Description		betaine--homocysteine S-methyltransferase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage
Pathways		Sulfur amino acid metabolism Choline catabolism
Drugs		Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine
Diseases
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610 23823483) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		635
HPRD ID		04200
Ensembl ID		ENSG00000145692
Uniprot IDs		Q93088 V9HWA4
PDB IDs		1LT7 1LT8 4M3P 8D45
Enriched GO Terms of Interacting Partners?		BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling
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