BHMT and ALG9

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BHMT	ALG9
Gene Name		betaine--homocysteine S-methyltransferase	ALG9, alpha-1,2-mannosyltransferase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Protein Complex Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Zinc Ion Binding S-adenosylmethionine-homocysteine S-methyltransferase Activity Protein Complex Binding Betaine-homocysteine S-methyltransferase Activity	Mannosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
	Biological Process	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Response To Organonitrogen Compound S-methylmethionine Cycle Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Mannosylation
Pathways		Sulfur amino acid metabolism Metabolism of amino acids and derivatives	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs		L-Methionine S-(D-Carboxybutyl)-L-Homocysteine Citric Acid
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610)
Protein-Protein Interactions		5 interactors: ALG9 BBS1 BBS2 BBS4 LAMTOR3	2 interactors: BHMT H2AFX
Entrez ID		635	79796
HPRD ID		04200	09504
Ensembl ID		ENSG00000145692
Uniprot IDs		E5RJH0 Q93088	Q9H6U8
PDB IDs		1LT7 1LT8
Enriched GO Terms of Interacting Partners?		Nonmotile Primary Cilium Assembly Photoreceptor Cell Maintenance Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Cellular Response To Leptin Stimulus Regulation Of Microtubule-based Movement Cilium Assembly Striatum Development Response To Leptin Visual Perception Sensory Perception Of Light Stimulus Tissue Homeostasis Cilium Organization Regulation Of Response To Food Cilium Morphogenesis Regulation Of Appetite Subpallium Development Golgi To Plasma Membrane Protein Transport Multicellular Organismal Homeostasis Cell Projection Assembly Golgi To Plasma Membrane Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Brain Morphogenesis Positive Regulation Of Multicellular Organism Growth Cellular Protein Localization Cellular Pigmentation Organelle Assembly Hippocampus Development Protein Localization To Organelle Establishment Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Limbic System Development Regulation Of Multicellular Organism Growth Protein Localization Pigmentation Fat Cell Differentiation Spermatid Development Sensory Perception Spermatid Differentiation Protein Localization To Plasma Membrane Cell Projection Morphogenesis Positive Regulation Of Developmental Growth Cerebral Cortex Development Cell Part Morphogenesis	S-methylmethionine Cycle S-methylmethionine Metabolic Process Amino-acid Betaine Catabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage Methionine Biosynthetic Process Amino-acid Betaine Metabolic Process Methionine Metabolic Process Sulfur Amino Acid Biosynthetic Process Positive Regulation Of DNA Repair Sulfur Amino Acid Metabolic Process Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleosome Assembly Regulation Of Response To DNA Damage Stimulus Cellular Amino Acid Biosynthetic Process Chromatin Assembly Nucleosome Organization Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly DNA Damage Checkpoint Protein-DNA Complex Assembly Protein Methylation DNA Packaging
Tagcloud ?		1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike	adbrk2 arntl dpysl2 drd3 dusp6 famine gad1 gch1 gnaz grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1
Tagcloud (Difference) ?		1236bp 3days 6days 6months abundances aestivation african annectens arousal betaine bhmt1 callorhinchus catalyses coding deleterious homocysteine lungfish methionine methyltransferase milii phases phylogenetic protopterus reconstruction returned tetrapods translationally unchanged unlike	adbrk2 arntl dpysl2 drd3 dusp6 famine gad1 gch1 gnaz grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1
Tagcloud (Intersection) ?