BHMT and ALG9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BHMT	ALG9
Description		betaine--homocysteine S-methyltransferase	ALG9 alpha-1,2-mannosyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity	Alpha-1,2-mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol Alpha-1,2-mannosyltransferase Activity
	Biological Process	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Sulfur amino acid metabolism Choline catabolism	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes CDG-1l
Drugs		Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610 23823483) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990)	A body shape index ( 34021172) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5	2 interacting genes: BHMT H2AX
Entrez ID		635	79796
HPRD ID		04200	09504
Ensembl ID		ENSG00000145692	ENSG00000086848
Uniprot IDs		Q93088 V9HWA4	Q9H6U8
PDB IDs		1LT7 1LT8 4M3P 8D45
Enriched GO Terms of Interacting Partners?		BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling	Betaine-homocysteine S-methyltransferase Activity Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process S-methyltransferase Activity Amino-acid Betaine Catabolic Process Vesicle Tethering Complex Protein Modification Process L-methionine Salvage CORVET Complex Methionine Biosynthetic Process Amino-acid Betaine Metabolic Process Sulfur Amino Acid Biosynthetic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process XY Body Chromatin-protein Adaptor Activity Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Protein Ubiquitination Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Protein Metabolic Process Replication Fork Modified Amino Acid Catabolic Process Protein Methylation Sulfur Amino Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Aspartate Family Amino Acid Metabolic Process Post-translational Protein Modification Site Of DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Condensed Nuclear Chromosome Male Germ Cell Nucleus Syntaxin Binding Endosome To Lysosome Transport
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