BICD1 and DCTN1

Number of citations of the paper that reports this interaction (PMID 17139249)
25

Data Source:
HPRD (in vivo)

		BICD1	DCTN1
Gene Name		bicaudal D homolog 1 (Drosophila)	dynactin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Tubulin Complex Perinuclear Region Of Cytoplasm Host Cell Viral Assembly Compartment	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Rab GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Binding	Motor Activity Protein Binding Dynein Binding
	Biological Process	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Viral Process Protein Localization To Organelle Stress Granule Assembly Positive Regulation Of Receptor-mediated Endocytosis Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C Activity Regulation Of Proteinase Activated Receptor Activity Negative Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process
Pathways			IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs
Diseases
GWAS		Emphysema-related traits ( 20709820) Normalized brain volume ( 19010793) Obesity-related traits ( 23251661) Pancreatic cancer ( 20686608)
Protein-Protein Interactions		12 interactors: ALPI CPNE4 DCTN1 DCTN2 DISC1 DYNC1I1 GSK3A GSK3B MAPK14 NIN RAB6A STAT3	42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B
Entrez ID		636	1639
HPRD ID		03730	07206
Ensembl ID		ENSG00000151746	ENSG00000204843
Uniprot IDs		A8MVZ6 Q96G01	Q14203 Q6MZZ3
PDB IDs			1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Negative Regulation Of Type B Pancreatic Cell Development Microtubule-based Process Hypermethylation Of CpG Island Cellular Localization Cellular Response To Interleukin-3 Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Generation Of Precursor Metabolites And Energy Antigen Processing And Presentation Regulation Of Wnt Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Immune System Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II ER-nucleus Signaling Pathway Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Microtubule-based Transport Organelle Localization Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Protein Modification Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Methylation Regulation Of Carbohydrate Metabolic Process Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Hypertrophy Response To Lithium Ion Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Melanosome Transport Regulation Of Glycogen Biosynthetic Process Pigment Granule Transport Cellular Response To Growth Factor Stimulus Vesicle Localization Establishment Of Melanosome Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Response To Growth Factor Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation	Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process
Tagcloud ?			als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Difference) ?			als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Intersection) ?