BICD1 and DYNC1I1

Number of citations of the paper that reports this interaction (PubMedID 28718761)
61

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo)

		BICD1	DYNC1I1
Description		BICD cargo adaptor 1	dynein cytoplasmic 1 intermediate chain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Cytoplasmic Microtubule Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Secretory Vesicle	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Dynein Complex Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Protein Kinase Binding Small GTPase Binding Proteinase Activated Receptor Binding Dynactin Binding Dynein Intermediate Chain Binding Dynein Complex Binding	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	RNA Processing Intracellular MRNA Localization Anatomical Structure Morphogenesis Virion Assembly Protein Localization To Organelle Stress Granule Assembly Constitutive Secretory Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Centrosome	Microtubule-based Movement Transport Along Microtubule Vesicle Transport Along Microtubule
Pathways		COPI-independent Golgi-to-ER retrograde traffic	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Emphysema-related traits ( 20709820) Fourth ventricle volume ( 31530798) Intralaminar thalamic nuclei volume ( 34006833) Left ventricular mass x antihypertensive treatment interaction ( 31407531) Normalized brain volume ( 19010793) Obesity-related traits ( 23251661) Pancreatic cancer ( 20686608) Parkinson's disease ( 32201043)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737 33830993) Obesity-related traits ( 23251661) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: ALPI CPNE4 DCTN1 DCTN2 DISC1 DSCAM DYNC1I1 FXR1 GSK3A GSK3B MAPK14 NIN PTPN23 RAB6A STAT3	35 interacting genes: ACADM ANXA7 BICD1 CADM4 CDKN1A DCTN1 DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 LCOR MCC NAGK NUDT21 PIN1 RAP1GAP RBPMS RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP YTHDF1
Entrez ID		636	1780
HPRD ID		03730	04798
Ensembl ID		ENSG00000151746	ENSG00000158560
Uniprot IDs		A8MVZ6 F8VZX7 Q96G01	A4D1I7 O14576 Q8N542
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Dynein Complex Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Developmental Growth Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Differentiation Glutamatergic Synapse Ciliary Basal Body Nervous System Development Regulation Of Glycogen (starch) Synthase Activity Regulation Of Growth Tau Protein Binding Regulation Of Axonogenesis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Microtubule Spindle Pole Negative Regulation Of Catabolic Process Regulation Of Cell Differentiation Cell Projection Organization Cellular Response To Interleukin-3 Regulation Of Mitochondrial Membrane Permeability Regulation Of Type B Pancreatic Cell Development Centriolar Subdistal Appendage Regulation Of Neuron Projection Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Membrane Permeability Protein Kinase Binding Regulation Of Cell Adhesion Microtubule Anchoring At Centrosome Microtubule-based Process Positive Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Axon Extension Beta-catenin Destruction Complex Centriole-centriole Cohesion Microtubule Anchoring At Microtubule Organizing Center Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Protein Kinase A Catalytic Subunit Binding Establishment Of Organelle Localization Organelle Organization Camera-type Eye Photoreceptor Cell Differentiation Positive Regulation Of Nervous System Development Positive Regulation Of Catabolic Process Regulation Of Multicellular Organismal Development Establishment Of Vesicle Localization	Dynein Intermediate Chain Binding Dynein Complex Cytoplasmic Dynein Complex Microtubule-based Process Microtubule Microtubule Associated Complex Tau Protein Binding Cytoplasmic Stress Granule Microtubule-based Movement Centrosome Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Intracellular Transport Stress Granule Assembly Identical Protein Binding Microtubule Cytoskeleton Organization Positive Regulation Of Protein Localization To Centrosome Cellular Component Assembly Regulation Of Long-term Synaptic Potentiation Cytoplasm Secretory Vesicle Regulation Of DNA Replication Ciliary Tip Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Response To Phorbol 13-acetate 12-myristate Intracellular MRNA Localization Regulation Of Protein Localization To Centrosome Positive Regulation Of Intracellular Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway MRNA Binding Microtubule Anchoring At Microtubule Organizing Center Microtubule Cytoskeleton Viral Process Mitotic Cell Cycle Phase Transition Dynactin Binding Replicative Senescence Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway MRNA Export From Nucleus Membraneless Organelle Assembly Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cellular Component Organization Negative Regulation Of Phosphate Metabolic Process Cell Cycle Phase Transition Scaffold Protein Binding Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Cytoskeleton Protein Kinase Binding Transport Along Microtubule Organelle Localization
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