FBLN5 and PDIA3

		FBLN5	PDIA3
Description		fibulin 5	protein disulfide isomerase family A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Tapasin-ERp57 Complex Extracellular Exosome
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity Identical Protein Binding LncRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class I Protein Complex Protein Folding Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation Extrinsic Apoptotic Signaling Pathway Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)
Interacting Genes		13 interacting genes: ATN1 GFI1B HOXA1 LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13	25 interacting genes: APP BACE1 CALR CANX CEBPA CFTR ERO1A ERP27 ESR1 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PCBP2 RBFOX2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A
Entrez ID		10516	2923
HPRD ID		05204	03625
Ensembl ID		ENSG00000140092	ENSG00000167004
Uniprot IDs		A0A024R6G3 A0A9L9PXD9 G3V2P8 G3V4U0 G3XA98 Q9UBX5	P30101 V9HVY3
PDB IDs			2ALB 2DMM 2H8L 3F8U 6ENY 7QNG 7QPD
Enriched GO Terms of Interacting Partners?		Copper Ion Binding Nuclear Matrix Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Heparin Binding Plasma Lipoprotein Particle Diencephalon Morphogenesis Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protease Binding Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Glycosaminoglycan Binding Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Type 8 Metabotropic Glutamate Receptor Binding Dendritic Spine Organization Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis RNA Topoisomerase Activity Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Negative Regulation Of Type II Interferon Production Postsynapse Organization	MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Chemical Homeostasis Protein Folding In Endoplasmic Reticulum Regulation Of Glycolytic Process Intracellular Receptor Signaling Pathway Homeostatic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of ATP Metabolic Process Cellular Homeostasis Endoplasmic Reticulum Lumen Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Hormone Response To Stress Negative Regulation Of RNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signal Transduction Amyloid Fibril Formation Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Protein-containing Complex Response To Ketone Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Proteolysis Response To Lipid Presynapse Response To Endoplasmic Reticulum Stress Positive Regulation Of Nitric Oxide Metabolic Process Enzyme Binding Regulation Of Generation Of Precursor Metabolites And Energy Organ Growth Regulation Of Protein Localization Cellular Response To Manganese Ion Hormone-mediated Signaling Pathway Monoatomic Cation Homeostasis Endoplasmic Reticulum Prostate Gland Growth L-ascorbic Acid Metabolic Process Monoatomic Ion Homeostasis Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of Interleukin-1 Beta Production Regulation Of Endocytosis
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