FBLN5 and SOD3

Number of citations of the paper that reports this interaction (PubMedID 15528465)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		FBLN5	SOD3
Description		fibulin 5	superoxide dismutase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Extracellular Exosome
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding Antioxidant Activity Oxidoreductase Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Adhesion Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals	Response To Hypoxia Superoxide Metabolic Process Removal Of Superoxide Radicals
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Benzoyl peroxide
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Blood protein levels ( 30072576) Major depressive disorder ( 23377640)
Interacting Genes		13 interacting genes: ATN1 GFI1B HOXA1 LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13	9 interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		10516	6649
HPRD ID		05204	01708
Ensembl ID		ENSG00000140092	ENSG00000109610
Uniprot IDs		A0A024R6G3 A0A9L9PXD9 G3V2P8 G3V4U0 G3XA98 Q9UBX5	A0A140VJU8 P08294
PDB IDs			2JLP
Enriched GO Terms of Interacting Partners?		Copper Ion Binding Nuclear Matrix Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Heparin Binding Plasma Lipoprotein Particle Diencephalon Morphogenesis Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protease Binding Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Glycosaminoglycan Binding Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Type 8 Metabotropic Glutamate Receptor Binding Dendritic Spine Organization Negative Regulation Of Interleukin-2 Production Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Mature Natural Killer Cell Chemotaxis RNA Topoisomerase Activity Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Negative Regulation Of Type II Interferon Production Postsynapse Organization	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Regulation Of Metal Ion Transport Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Regulation Of Monoatomic Ion Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Calcium Ion Binding Polyubiquitin Modification-dependent Protein Binding Response To Endoplasmic Reticulum Stress Potassium Channel Regulator Activity Positive Regulation Of Protein Metabolic Process Intramembranous Bone Growth Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Protein Targeting To Membrane Regulation Of Transport Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Protein Catabolic Process Autophagosome Regulation Of Potassium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Kv4.3-KChIP1 Channel Complex Autophagosome Assembly Autophagosome Organization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Monoatomic Ion Channel Complex BAT3 Complex Binding Localization Within Membrane Negative Regulation Of Clathrin-dependent Endocytosis Transmembrane Transporter Binding
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