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FBLN5
Description
fibulin 5
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Molecular Function
Integrin Binding
Calcium Ion Binding
Protein Binding
Extracellular Matrix Constituent Conferring Elasticity
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Cell-matrix Adhesion
Negative Regulation Of Angiogenesis
Extracellular Matrix Organization
Positive Regulation Of Osteoblast Proliferation
Protein Localization To Cell Surface
Positive Regulation Of Transcription By RNA Polymerase II
Secretion
Elastic Fiber Assembly
Intramembranous Bone Growth
Regulation Of Removal Of Superoxide Radicals
Pathways
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS
Diastolic blood pressure (
30578418
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Heel bone mineral density (
30598549
)
Height (
18391951
25429064
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Major depressive disorder (
34099189
)
Major depressive disorder x sex interaction (
34099189
)
Optic disc size (
31809533
)
Pulse pressure (
27841878
30578418
)
Waist circumference adjusted for body mass index (
28552196
)
Novel Interacting Genes
10 novel interacting genes:
COXFA4
GSC
LGMN
PDIA3
PPP2R5C
PSMC1
SERPINA1
SERPINA5
ST3GAL3
XCL1
Interacting Genes
13 interacting genes:
ATN1
GFI1B
HOXA1
LOXL1
LPA
MEOX2
NUFIP2
OTX1
PAXIP1
PRNP
SOD3
TOP3B
TRIP13
Entrez ID
10516
HPRD ID
05204
Ensembl ID
ENSG00000140092
Uniprot IDs
A0A024R6G3
A0A9L9PXD9
G3V2P8
G3V4U0
G3XA98
Q9UBX5
PDB IDs
Enriched GO Terms of Interacting Partners
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Copper Ion Binding
Nuclear Matrix
Semicircular Canal Formation
Sequence-specific Double-stranded DNA Binding
Heparin Binding
Plasma Lipoprotein Particle
Diencephalon Morphogenesis
Protein C Inhibitor-coagulation Factor V Complex
Protein C Inhibitor-TMPRSS7 Complex
Protein C Inhibitor-PLAU Complex
Protein C Inhibitor-TMPRSS11E Complex
Protease Binding
Protein C Inhibitor-coagulation Factor Xa Complex
Protein C Inhibitor-KLK3 Complex
Protein C Inhibitor-plasma Kallikrein Complex
Glycosaminoglycan Binding
Protein C Inhibitor-thrombin Complex
Protein C Inhibitor-coagulation Factor XI Complex
Protein C Inhibitor-PLAT Complex
Type 8 Metabotropic Glutamate Receptor Binding
Dendritic Spine Organization
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Granzyme A Production
Negative Regulation Of T-helper 1 Cell Activation
Positive Regulation Of Immunoglobulin Mediated Immune Response
Positive Regulation Of Immunoglobulin Production In Mucosal Tissue
Mature Natural Killer Cell Chemotaxis
RNA Topoisomerase Activity
Regulation Of Long-term Synaptic Potentiation
Neuron Projection Organization
Negative Regulation Of Type II Interferon Production
Postsynapse Organization
Tagcloud
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