SEC23A and DCTN1

Number of citations of the paper that reports this interaction (PMID 15580264)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SEC23A	DCTN1
Gene Name		Sec23 homolog A (S. cerevisiae)	dynactin 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Smooth Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Kinetochore Spindle Pole Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Retromer Complex Cell Leading Edge
	Molecular Function	Protein Binding Zinc Ion Binding	Motor Activity Protein Binding Dynein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Membrane Organization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Organelle Organization Mitotic Nuclear Division Nervous System Development Microtubule-based Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Melanosome Transport Retrograde Transport, Endosome To Golgi Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System	IRE1alpha activates chaperones MHC class II antigen presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CDK16 CDK18 DCTN1 GLRA2 NDRG1 SDCBP2 SEC16A SEC24B SEC24C	42 interactors: ACTR1A ACTR1B AKT1 APEX1 BBS1 BBS4 BICD1 BICD2 CASP2 CASP3 CASP7 CDC37 CLIP1 DCTN3 DISC1 DST DTNBP1 DYNC1I2 FBXL5 GRB2 GSK3B HAP1 KIAA0408 KIF11 MAP2K3 MAP2K6 MAPRE1 MED14 MTERF1 NEK2 PAFAH1B1 PFDN1 PGAM1 PPP1CA RAB6A RBL2 RPGR SEC23A SPTBN2 STAT1 VIM ZNF512B
Entrez ID		10484	1639
HPRD ID		06714	07206
Ensembl ID		ENSG00000100934	ENSG00000204843
Uniprot IDs		B3KXI2 F5H365 Q15436	Q14203 Q6MZZ3
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX	1TXQ 2COY 2HKN 2HKQ 2HL3 2HL5 2HQH 3E2U 3TQ7
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Establishment Of Vesicle Localization Vesicle Localization Membrane Budding Establishment Of Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ER To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Establishment Of Localization In Cell Nervous System Development Vesicle Organization Cellular Localization Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport Golgi Vesicle Transport Intracellular Transport Antigen Processing And Presentation Membrane Organization Neural Nucleus Development Transport Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Regulation Of Cargo Loading Into COPII-coated Vesicle Cochlear Nucleus Development System Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cytoplasmic Transport Pulmonary Artery Morphogenesis Positive Regulation Of Spindle Checkpoint Coronary Artery Morphogenesis Post-translational Protein Modification Growth Hormone Secretion Multicellular Organismal Development Auditory Receptor Cell Stereocilium Organization Anatomical Structure Development Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Coronary Vasculature Morphogenesis Pons Development Lung Lobe Morphogenesis Auditory Receptor Cell Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Protein Complex Assembly Immune System Process	Cell Cycle Microtubule-based Process Organelle Organization Cell Cycle Process Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Microtubule-based Movement Microtubule-based Transport Regulation Of Cell Cycle Cytoskeleton-dependent Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Process Regulation Of Microtubule-based Process Antigen Processing And Presentation Organelle Transport Along Microtubule Immune System Process Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Execution Phase Of Apoptosis Cellular Protein Localization Cytoskeleton Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Localization Cellular Localization Microtubule Anchoring At Microtubule Organizing Center Neurotrophin TRK Receptor Signaling Pathway Regulation Of Metabolic Process Neurotrophin Signaling Pathway Regulation Of Organelle Organization Establishment Of Localization In Cell Protein Localization To Cytoskeleton Cell Division Generation Of Neurons Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Cilium Assembly Organelle Assembly Neurogenesis Mitotic Nuclear Division Anatomical Structure Development Regulation Of Cell Projection Organization Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Process
Tagcloud ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates golgi hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Difference) ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates golgi hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	als2 c147r causative chmp2b dao diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate setx sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp
Tagcloud (Intersection) ?