SEC23A and SEC24B

Number of citations of the paper that reports this interaction (PMID 10075675)
19

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SEC23A	SEC24B
Gene Name		Sec23 homolog A (S. cerevisiae)	SEC24 family member B
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Smooth Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding	Transporter Activity Protein Binding Zinc Ion Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Membrane Organization	Neural Tube Closure Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Outflow Tract Morphogenesis Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cochlear Nucleus Development Aorta Morphogenesis Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Auditory Receptor Cell Stereocilium Organization Lung Lobe Morphogenesis Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Cargo Loading Into COPII-coated Vesicle
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System	Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CDK16 CDK18 DCTN1 GLRA2 NDRG1 SDCBP2 SEC16A SEC24B SEC24C	2 interactors: SCAP SEC23A
Entrez ID		10484	10427
HPRD ID		06714	06216
Ensembl ID		ENSG00000100934	ENSG00000138802
Uniprot IDs		B3KXI2 F5H365 Q15436	B7ZKM8 O95487
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX	3EH1
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Establishment Of Vesicle Localization Vesicle Localization Membrane Budding Establishment Of Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ER To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Establishment Of Localization In Cell Nervous System Development Vesicle Organization Cellular Localization Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport Golgi Vesicle Transport Intracellular Transport Antigen Processing And Presentation Membrane Organization Neural Nucleus Development Transport Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Regulation Of Cargo Loading Into COPII-coated Vesicle Cochlear Nucleus Development System Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cytoplasmic Transport Pulmonary Artery Morphogenesis Positive Regulation Of Spindle Checkpoint Coronary Artery Morphogenesis Post-translational Protein Modification Growth Hormone Secretion Multicellular Organismal Development Auditory Receptor Cell Stereocilium Organization Anatomical Structure Development Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Coronary Vasculature Morphogenesis Pons Development Lung Lobe Morphogenesis Auditory Receptor Cell Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Protein Complex Assembly Immune System Process	Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process SREBP Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Response To Sterol Depletion Regulation Of Receptor Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process COPII Vesicle Coating COPII-coated Vesicle Budding Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Vesicle Targeting, To, From Or Within Golgi Regulation Of Fatty Acid Biosynthetic Process Localization Within Membrane Vesicle Targeting Negative Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Membrane Budding Regulation Of Fatty Acid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Steroid Metabolic Process ER To Golgi Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Vascular Endothelial Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cholesterol Metabolic Process Small Molecule Metabolic Process Protein N-linked Glycosylation Sterol Metabolic Process Regulation Of Lipid Biosynthetic Process
Tagcloud ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates golgi hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Difference) ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Intersection) ?		golgi