SEC23A and ERLIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC23A	ERLIN1
Description		SEC23 homolog A, COPII component	ER lipid raft associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein-containing Complex Membrane Raft
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Lipid Binding Cholesterol Binding Ubiquitin Protein Ligase Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process SREBP Signaling Pathway ERAD Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases		Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Metabolite levels ( 23823483) Vitamin D levels ( 29343764)	Alanine aminotransferase levels ( 34315874 33547301 33339817) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Response to radiotherapy in cancer (late toxicity) ( 24785509) Squamous cell lung carcinoma ( 28604730) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23IP SEC24B SEC24C SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11	8 interacting genes: AGR3 BNIP2 FA2H FILNC1 RBFA SEC22A SEC23A VMA12
Entrez ID		10484	10613
HPRD ID		06714	08502
Ensembl ID		ENSG00000100934	ENSG00000107566
Uniprot IDs		Q15436	O75477
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Protein Localization To Endoplasmic Reticulum Exit Site Vesicle Cargo Loading Protein Localization To Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane COPII-coated Vesicle Cargo Loading Vesicle-mediated Transport Membrane Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Intracellular Transport Regulation Of Plasma Membrane Organization COPII Vesicle Coat Lipoprotein Transport Establishment Of Protein Localization Positive Regulation Of Mitochondrial Fission Mitochondrial Calcium Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Protein Transport	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Central Nervous System Myelin Maintenance Membrane Organization COPII-coated Vesicle Budding Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Proton-transporting V-type ATPase Complex Assembly Peripheral Nervous System Myelin Maintenance Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activator Activity COPII Vesicle Coat Golgi Vesicle Transport Myelin Maintenance Plasma Membrane Raft Organization Glycosylceramide Metabolic Process COPI-coated Vesicle Membrane Lysosomal Protein Catabolic Process Oxysterol Binding Vacuolar Proton-transporting V-type ATPase Complex Cellular Response To Increased Oxygen Levels Protein Catabolic Process In The Vacuole Dystroglycan Binding COPII-coated Vesicle Cargo Loading
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