SEC23A and SEC16A

Number of citations of the paper that reports this interaction (PMID 17192411)
36

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SEC23A	SEC16A
Gene Name		Sec23 homolog A (S. cerevisiae)	SEC16 homolog A (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Smooth Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Membrane Organization	Endoplasmic Reticulum Organization Protein Transport Substantia Nigra Development COPII Vesicle Coating
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs
Diseases
GWAS			Ulcerative colitis ( 21297633)
Protein-Protein Interactions		9 interactors: CDK16 CDK18 DCTN1 GLRA2 NDRG1 SDCBP2 SEC16A SEC24B SEC24C	1 interactors: SEC23A
Entrez ID		10484	9919
HPRD ID		06714	11075
Ensembl ID		ENSG00000100934	ENSG00000148396
Uniprot IDs		B3KXI2 F5H365 Q15436	F1T0I1 J3KNL6 O15027
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX
Enriched GO Terms of Interacting Partners?		COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Establishment Of Vesicle Localization Vesicle Localization Membrane Budding Establishment Of Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ER To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Organelle Localization Establishment Of Localization In Cell Nervous System Development Vesicle Organization Cellular Localization Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport Golgi Vesicle Transport Intracellular Transport Antigen Processing And Presentation Membrane Organization Neural Nucleus Development Transport Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Regulation Of Cargo Loading Into COPII-coated Vesicle Cochlear Nucleus Development System Development Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cytoplasmic Transport Pulmonary Artery Morphogenesis Positive Regulation Of Spindle Checkpoint Coronary Artery Morphogenesis Post-translational Protein Modification Growth Hormone Secretion Multicellular Organismal Development Auditory Receptor Cell Stereocilium Organization Anatomical Structure Development Positive Regulation Of Cell Cycle Checkpoint Regulation Of Cell Cycle Coronary Vasculature Morphogenesis Pons Development Lung Lobe Morphogenesis Auditory Receptor Cell Morphogenesis Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Protein Complex Assembly Immune System Process	COPII Vesicle Coating COPII-coated Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Membrane Budding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II ER To Golgi Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Protein N-linked Glycosylation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Organization Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Antigen Processing And Presentation Establishment Of Organelle Localization Macromolecule Glycosylation Protein Glycosylation Glycosylation Glycoprotein Biosynthetic Process Organelle Localization Glycoprotein Metabolic Process
Tagcloud ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates golgi hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	anchoring anterograde dendritic deres dispersion elusive endoplasmic eres exit export golgi gtpase impaired interacted interfered leucine locally lrrk2 missense onto parkinson pathogenic pd physiological r1441c repeat spines synapse transport
Tagcloud (Difference) ?		allow atf6 bbf2h7 canonical cartilage chondrocytes cleaved contrary dual expresses facilitates hedgehog indian luminal neighbouring patched preferentially processed promote resident secreted simultaneously structurally terminus trafficking transducers transmembrane triggered	anchoring anterograde dendritic deres dispersion elusive endoplasmic eres exit export gtpase impaired interacted interfered leucine locally lrrk2 missense onto parkinson pathogenic pd physiological r1441c repeat spines synapse transport
Tagcloud (Intersection) ?		golgi