RC3H2 and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 26489670)
51

Data Source:
BioGRID (pull down)

		RC3H2	UBE2G2
Description		ring finger and CCCH-type domains 2	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	P-body Cytoplasm Cell Surface Cytoplasmic Stress Granule Membrane	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding Zinc Ion Binding Transferase Activity RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay B Cell Homeostasis Ubiquitin-dependent Protein Catabolic Process Post-embryonic Development Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		13 interacting genes: TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		54542	7327
HPRD ID		14726	04387
Ensembl ID		ENSG00000056586	ENSG00000184787
Uniprot IDs		A6NHN2 Q9HBD1	P60604
PDB IDs		4Z30 4Z31 4ZLC 4ZLD	2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Postreplication Repair Positive Regulation Of Protein K63-linked Ubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process ATP Binding Regulation Of Protein K63-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Error-free Postreplication DNA Repair Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleus Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process DNA Double-strand Break Processing Cellular Response To Interferon-beta DNA Damage Response Catabolic Process Response To Interferon-beta Regulation Of DNA Metabolic Process Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Positive Regulation Of Signal Transduction Regulation Of DNA Repair SUMO Conjugating Enzyme Activity	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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