RC3H2 and UBE2Q2

Number of citations of the paper that reports this interaction (PubMedID 26489670)
51

Data Source:
BioGRID (pull down)

		RC3H2	UBE2Q2
Description		ring finger and CCCH-type domains 2	ubiquitin conjugating enzyme E2 Q2
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GO Annotations	Cellular Component	P-body Cytoplasm Cell Surface Cytoplasmic Stress Granule Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding Zinc Ion Binding Transferase Activity RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay B Cell Homeostasis Ubiquitin-dependent Protein Catabolic Process Post-embryonic Development Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process	Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)	Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31015462 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 33832965) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Triglyceride levels in HIV infection ( 33109212) Urate levels ( 23263486 31985003) Urate levels in obese individuals ( 25811787)
Interacting Genes		13 interacting genes: TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2	11 interacting genes: BIRC2 BIRC3 HECTD3 ITCH MDM2 PCGF2 RC3H2 RNF111 RNF31 UBA1 UBC
Entrez ID		54542	92912
HPRD ID		14726	14294
Ensembl ID		ENSG00000056586	ENSG00000140367
Uniprot IDs		A6NHN2 Q9HBD1	Q8WVN8
PDB IDs		4Z30 4Z31 4ZLC 4ZLD	1ZUO
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Postreplication Repair Positive Regulation Of Protein K63-linked Ubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process ATP Binding Regulation Of Protein K63-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Error-free Postreplication DNA Repair Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleus Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process DNA Double-strand Break Processing Cellular Response To Interferon-beta DNA Damage Response Catabolic Process Response To Interferon-beta Regulation Of DNA Metabolic Process Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Positive Regulation Of Signal Transduction Regulation Of DNA Repair SUMO Conjugating Enzyme Activity	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Necroptotic Process Ubiquitin-protein Transferase Activity Regulation Of Programmed Necrotic Cell Death Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Transferase Activity Catabolic Process Protein Metabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification CD40 Receptor Complex Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Zinc Ion Binding Ligase Activity Protein-containing Complex Positive Regulation Of Post-translational Protein Modification Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Proteasomal Protein Catabolic Process Regulation Of Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Toll-like Receptor Signaling Pathway Ribonucleoprotein Complex Binding Positive Regulation Of Catabolic Process Macromolecule Metabolic Process
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