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ZBTB18 and DNMT3A
Number of citations of the paper that reports this interaction (PMID
11350943
)
103
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
ZBTB18
DNMT3A
Gene Name
zinc finger and BTB domain containing 18
DNA (cytosine-5-)-methyltransferase 3 alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleus
Nucleoplasm
Microtubule Cytoskeleton
Intercellular Bridge
Chromosome, Centromeric Region
Euchromatin
XY Body
Nucleus
Nucleoplasm
Nuclear Heterochromatin
Cytoplasm
Nuclear Matrix
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Sequence-specific DNA Binding
Metal Ion Binding
DNA Binding
Chromatin Binding
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
DNA-methyltransferase Activity
Identical Protein Binding
Unmethylated CpG Binding
Metal Ion Binding
DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Transcription, DNA-templated
Skeletal Muscle Tissue Development
Cerebellum Development
Hippocampus Development
Cerebral Cortex Development
Negative Regulation Of Transcription, DNA-templated
Neuron Development
Homeostasis Of Number Of Cells
Regulation Of Cell Division
Negative Regulation Of Transcription From RNA Polymerase II Promoter
DNA Methylation
Chromatin Organization
Methylation-dependent Chromatin Silencing
Regulation Of Gene Expression By Genetic Imprinting
Spermatogenesis
DNA Methylation On Cytosine Within A CG Sequence
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
DNA Methylation Involved In Embryo Development
DNA Methylation Involved In Gamete Generation
Hypermethylation Of CpG Island
Negative Regulation Of Gene Expression, Epigenetic
S-adenosylhomocysteine Metabolic Process
S-adenosylmethioninamine Metabolic Process
Cellular Response To Amino Acid Stimulus
C-5 Methylation Of Cytosine
Pathways
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
PRC2 methylates histones and DNA
RMTs methylate histone arginines
DNA methylation
Drugs
Diseases
GWAS
Crohn's disease (
21102463
)
Height (
18391951
)
Type 1 diabetes (
21980299
)
Protein-Protein Interactions
7 interactors:
CTBP1
CTBP2
DNMT3A
DNMT3B
PAK1
POMGNT1
TSN
31 interactors:
CBX1
DNMT1
DNMT3B
DNMT3L
EED
EHMT1
EHMT2
EZH2
F8A1
HDAC1
HIST1H3A
HIST1H3E
MYC
NRIP1
PIAS1
PRMT5
PTGES3
RB1
RPS8
SETDB1
SP100
SPI1
SUMO1
SUV39H1
TCL1A
TERF2IP
UBE2I
UHRF1
USP7
ZBTB17
ZBTB18
Entrez ID
10472
1788
HPRD ID
12231
04141
Ensembl ID
ENSG00000179456
ENSG00000119772
Uniprot IDs
Q99592
Q9Y6K1
PDB IDs
2QRV
3A1A
3A1B
3LLR
3SVM
Enriched GO Terms of Interacting Partners
?
S-adenosylmethioninamine Metabolic Process
DNA Methylation On Cytosine Within A CG Sequence
C-5 Methylation Of Cytosine
S-adenosylhomocysteine Metabolic Process
Methylation-dependent Chromatin Silencing
DNA Methylation On Cytosine
White Fat Cell Differentiation
Chromatin Modification
Viral Genome Replication
Chromatin Organization
Regulation Of Gene Expression By Genetic Imprinting
Chromatin Silencing
Genetic Imprinting
Regulation Of Transcription From RNA Polymerase II Promoter
Gene Expression
Chromosome Organization
DNA Methylation
Cellular Response To Amino Acid Stimulus
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Organelle Organization
Positive Regulation Of Histone Modification
Negative Regulation Of Gene Expression, Epigenetic
Cellular Response To Organonitrogen Compound
DNA Modification
Negative Regulation Of Chromosome Organization
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Gene Silencing
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Amino Acid
Cellular Nitrogen Compound Metabolic Process
Fat Cell Differentiation
Regulation Of Histone Modification
Negative Regulation Of Cell Proliferation
Nitrogen Compound Metabolic Process
Cellular Response To Acid Chemical
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Hypermethylation Of CpG Island
Response To Organonitrogen Compound
Viral Life Cycle
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Regulation Of Chromosome Organization
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Chromatin Binding
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Chromosome Organization
Chromatin Organization
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression, Epigenetic
DNA Methylation On Cytosine
Chromatin Modification
DNA Methylation
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Nucleobase-containing Compound Metabolic Process
Methylation
DNA Modification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Organelle Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Histone Modification
Gene Expression
DNA Metabolic Process
Peptidyl-lysine Modification
RNA Biosynthetic Process
Histone Methylation
Regulation Of Metabolic Process
Transcription, DNA-templated
Histone H3-K9 Modification
Protein Methylation
Cellular Macromolecule Biosynthetic Process
RNA Metabolic Process
Regulation Of Chromosome Organization
Macromolecule Biosynthetic Process
Histone H3-K9 Methylation
Maintenance Of DNA Methylation
Cellular Metabolic Process
Histone Lysine Methylation
Peptidyl-lysine Methylation
Chromatin Silencing
Peptidyl-amino Acid Modification
Tagcloud
?
cpg
cues
de
dense
dnmt1
dnmts
enhancers
ensure
ensures
establishment
excluded
guide
lethal
localize
methylated
methylation
methylome
methyltransferase
methyltransferases
novo
nucleosomes
observe
preferential
promoters
pwwp
reflects
setd2
transcribed
Tagcloud (Difference)
?
cpg
cues
de
dense
dnmt1
dnmts
enhancers
ensure
ensures
establishment
excluded
guide
lethal
localize
methylated
methylation
methylome
methyltransferase
methyltransferases
novo
nucleosomes
observe
preferential
promoters
pwwp
reflects
setd2
transcribed
Tagcloud (Intersection)
?