ZBTB18 and MYLIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB18	MYLIP
Description		zinc finger and BTB domain containing 18	myosin regulatory light chain interacting protein
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Nuclear Speck	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways			VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258) Mercury levels ( 26025379)	Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 20864672 24097068 25961943) LDL cholesterol levels ( 32203549 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)
Interacting Genes		9 interacting genes: DNMT3A DNMT3B LINC02774 MYLIP PAK1 PIK3R3 POMGNT1 TSN ZBTB2	42 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LDLR LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438
Entrez ID		10472	29116
HPRD ID		12231	17621
Ensembl ID		ENSG00000179456	ENSG00000007944
Uniprot IDs		Q99592	Q5TIA5 Q8WY64
PDB IDs		8P2P	2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?		DNA (cytosine-5-)-methyltransferase Activity Catalytic Complex DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Fc Receptor Signaling Pathway Regulation Of B Cell Antigen Processing And Presentation Cerebellum Development Fc-gamma Receptor Signaling Pathway Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Protein-cysteine Methyltransferase Activity Transferase Activity DNA-methyltransferase Activity Regulation Of Immune Complex Clearance By Monocytes And Macrophages Low-affinity IgG Receptor Activity Negative Regulation Of Cytotoxic T Cell Degranulation Follicular Dendritic Cell Activation Immune Complex Clearance Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Beta-1,3-galactosyl-O-glycosyl-glycoprotein Beta-1,3-N-acetylglucosaminyltransferase Activity	Very-low-density Lipoprotein Particle Receptor Activity Ubiquitin Conjugating Enzyme Activity Reelin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Low-density Lipoprotein Particle Receptor Activity Reelin Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Binding Cerebral Cortex Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Ventral Spinal Cord Development Negative Regulation Of Macromolecule Metabolic Process Nucleus Ubiquitin-protein Transferase Activity Protein-containing Complex Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Dendrite Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hippocampus Development Cellular Response To Estrogen Stimulus Identical Protein Binding Apolipoprotein Binding Regulation Of Low-density Lipoprotein Particle Clearance
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