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ZNHIT1 and MAPK11
Number of citations of the paper that reports this interaction (PMID
17380123
)
14
Data Source:
HPRD
(two hybrid)
ZNHIT1
MAPK11
Gene Name
zinc finger, HIT-type containing 1
mitogen-activated protein kinase 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Swr1 Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
Nucleosome Binding
Histone Deacetylase Binding
Metal Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Histone Deacetylation
Regulation Of T Cell Proliferation
Histone Exchange
Negative Regulation Of G0 To G1 Transition
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription, DNA-templated
Protein Phosphorylation
Response To Stress
Organelle Organization
Mitochondrion Organization
Signal Transduction
Ras Protein Signal Transduction
Gene Expression
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Muscle Cell Differentiation
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Muscle Cell Differentiation
Stress-activated MAPK Cascade
Pathways
Cellular Senescence
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
p38MAPK events
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
activated TAK1 mediates p38 MAPK activation
Regulation of mRNA stability by proteins that bind AU-rich elements
CDO in myogenesis
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 2 (TLR2) Cascade
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Myogenesis
Signaling by VEGF
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Signalling to RAS
Signalling to ERKs
Organelle biogenesis and maintenance
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Mitochondrial biogenesis
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
DSCAM interactions
Oxidative Stress Induced Senescence
KSRP destabilizes mRNA
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
CSNK2B
HINFP
KRTAP10-7
MAPK11
MAPK14
TNIP1
TP53
27 interactors:
APP
ATF2
BCL2
C9orf78
CCND1
CPNE6
DUSP10
DUSP16
EEF2K
ELK1
ELK4
ESR2
HDAC3
HTRA2
JUN
MAPKAPK3
MAPKAPK5
MAPT
MBP
NOXA1
PML
POLR3D
RPS6KA5
SH2D1A
SOCS3
TAB1
ZNHIT1
Entrez ID
10467
5600
HPRD ID
15892
04208
Ensembl ID
ENSG00000106400
ENSG00000185386
Uniprot IDs
O43257
L7RT27
Q15759
PDB IDs
3GC8
3GC9
3GP0
Enriched GO Terms of Interacting Partners
?
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Stress-induced Premature Senescence
Regulation Of Phosphorylation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
DNA Damage Checkpoint
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Ras Protein Signal Transduction
Cell Cycle Checkpoint
Regulation Of Innate Immune Response
Cellular Senescence
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Muscle Cell Differentiation
Myoblast Differentiation
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Ionizing Radiation
Mitochondrion Organization
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Cell Aging
Cell Cycle
Immune Response-regulating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Muscle Structure Development
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Gene Expression
Regulation Of Innate Immune Response
Regulation Of Protein Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Innate Immune Response
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
Regulation Of Immune System Process
Defense Response
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Response To Stress
Signal Transduction By Phosphorylation
Regulation Of Immune Response
Cellular Response To Stress
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Response To Organic Substance
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Immune Response
Phosphorylation
Signaling
Cellular Response To Organic Substance
Regulation Of Signal Transduction
Cell Communication
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Signaling
Immune System Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Response To Lipid
Response To Growth Factor
Intracellular Signal Transduction
Regulation Of Growth
Tagcloud
?
antagonists
antitumor
bbc3
bcl2
ca
cacna1g
caco2
cdkn1a
channel
channels
express
hct116
knockdown
mapkalpha
occupancy
p21cip1
p38
p53
p53wt
promoted
puma
rationale
rnai
sb203580
ser392
stably
thought
Tagcloud (Difference)
?
antagonists
antitumor
bbc3
bcl2
ca
cacna1g
caco2
cdkn1a
channel
channels
express
hct116
knockdown
mapkalpha
occupancy
p21cip1
p38
p53
p53wt
promoted
puma
rationale
rnai
sb203580
ser392
stably
thought
Tagcloud (Intersection)
?