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ZNHIT1 and MAPK14
Number of citations of the paper that reports this interaction (PMID
17380123
)
14
Data Source:
HPRD
(two hybrid, in vitro)
ZNHIT1
MAPK14
Gene Name
zinc finger, HIT-type containing 1
mitogen-activated protein kinase 14
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Swr1 Complex
Nucleus
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Nucleosome Binding
Histone Deacetylase Binding
Metal Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
NFAT Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Histone Deacetylation
Regulation Of T Cell Proliferation
Histone Exchange
Negative Regulation Of G0 To G1 Transition
DNA Damage Checkpoint
Activation Of MAPK Activity
Cell Morphogenesis
Cartilage Condensation
Angiogenesis
Chondrocyte Differentiation
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Glucose Metabolic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
Movement Of Cell Or Subcellular Component
Chemotaxis
Organelle Organization
Mitochondrion Organization
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Ras Protein Signal Transduction
Skeletal Muscle Tissue Development
Blood Coagulation
Gene Expression
Positive Regulation Of Myotube Differentiation
Myoblast Differentiation Involved In Skeletal Muscle Regeneration
Peptidyl-serine Phosphorylation
Fatty Acid Oxidation
Platelet Activation
Osteoclast Differentiation
Lipopolysaccharide-mediated Signaling Pathway
Response To Muramyl Dipeptide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
P38MAPK Cascade
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Muscle Cell Differentiation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Innate Immune Response
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Striated Muscle Cell Differentiation
Positive Regulation Of Muscle Cell Differentiation
Stress-activated MAPK Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Ionizing Radiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Brown Fat Cell Differentiation
Stress-induced Premature Senescence
Positive Regulation Of Myoblast Fusion
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
ADP signalling through P2Y purinoceptor 1
Cellular Senescence
Toll Like Receptor TLR1:TLR2 Cascade
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
p38MAPK events
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
activated TAK1 mediates p38 MAPK activation
Regulation of mRNA stability by proteins that bind AU-rich elements
CDO in myogenesis
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Myogenesis
Signaling by VEGF
Platelet sensitization by LDL
Signalling to RAS
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Platelet activation, signaling and aggregation
Signalling to ERKs
Organelle biogenesis and maintenance
Toll Like Receptor 7/8 (TLR7/8) Cascade
Signal amplification
VEGFA-VEGFR2 Pathway
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Mitochondrial biogenesis
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
DSCAM interactions
KSRP destabilizes mRNA
Oxidative Stress Induced Senescence
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine
N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N\'-(4-Chlorophenyl)Urea
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
Inhibitor of P38 Kinase
6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine
3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine
1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
3-(Benzyloxy)Pyridin-2-Amine
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea
2-Chlorophenol
4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole
SB220025
4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
Triazolopyridine
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide
5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE
4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
N-cyclopropyl-2\',6-dimethyl-4\'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide
4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde
N-(3-cyanophenyl)-2\'-methyl-5\'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
N-(cyclopropylmethyl)-2\'-methyl-5\'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide
N~3~-cyclopropyl-N~4~\'-(cyclopropylmethyl)-6-methylbiphenyl-3,4\'-dicarboxamide
3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide
2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol
N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N\'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA
N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-
3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
3-FLUORO-N-1H-INDOL-5-YL-5-MORPHOLIN-4-YLBENZAMIDE
3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE
N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide
N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
CSNK2B
HINFP
KRTAP10-7
MAPK11
MAPK14
TNIP1
TP53
142 interactors:
AES
AIMP1
AKT1
ATF2
BAZ1B
BCL2
BICD1
BMI1
CCDC14
CCDC97
CD4
CDC25A
CDC25B
CDC25C
CDX2
CENPC
CEP164
COPS5
CREB1
CSNK2A1
CSNK2A2
CSNK2B
DDIT3
DDX26B
DUSP1
DUSP10
DUSP16
DUSP2
DUSP22
DUSP4
DUSP7
DUSP9
DYRK1B
EEA1
EEF1A1
EEF2K
EGFR
EIF4EBP1
ELK1
ELK3
ELMSAN1
EPB42
ESR1
ETV1
FKBP8
FLNA
FUBP1
GADD45A
GDF15
GMFB
GORASP2
GRB2
HDAC3
HIVEP1
HNF4A
HSF4
HTRA2
IRAK1
JDP2
JUN
JUNB
KARS
KAT2B
KMT2C
KRT18
KRT8
LIMK1
MAFA
MAP2K1
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAP3K10
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MAPKAPK3
MAPKAPK5
MARS
MAX
MBP
MEF2A
MEF2C
MEF2D
MITF
MKNK1
MKNK2
MOB3B
MUC12
NCOA3
NFATC1
NFATC4
NKTR
NUP153
PAK6
PHC2
PI4K2B
PLA2G4A
PLG
PML
PPARGC1A
PTPN7
RBSN
RELA
RET
ROBO1
RPL22
RPL41
RPS6KA4
RPS6KA5
SCN8A
SH2D1A
SHC1
SLC9A1
SMAD3
SMAD7
SMARCD3
SMEK1
SNAPIN
SPAG9
SPTBN1
SQSTM1
SRPK1
SRSF5
STAT1
STAT4
STK39
SUPT20H
TAB1
TCF20
TFCP2
TMEM63B
TP53
TRAF6
UGT2B10
YY1AP1
ZFP36L1
ZNF142
ZNHIT1
Entrez ID
10467
1432
HPRD ID
15892
02619
Ensembl ID
ENSG00000106400
ENSG00000112062
Uniprot IDs
O43257
L7RSM2
Q16539
PDB IDs
1A9U
1BL6
1BL7
1BMK
1DI9
1IAN
1KV1
1KV2
1M7Q
1OUK
1OUY
1OVE
1OZ1
1R39
1R3C
1W7H
1W82
1W83
1W84
1WBN
1WBO
1WBS
1WBT
1WBV
1WBW
1WFC
1YQJ
1ZYJ
1ZZ2
1ZZL
2BAJ
2BAK
2BAL
2BAQ
2FSL
2FSM
2FSO
2FST
2GFS
2I0H
2LGC
2NPQ
2OKR
2ONL
2QD9
2RG5
2RG6
2Y8O
2YIS
2YIW
2YIX
2ZAZ
2ZB0
2ZB1
3BV2
3BV3
3BX5
3C5U
3CTQ
3D7Z
3D83
3DS6
3DT1
3E92
3E93
3FC1
3FI4
3FKL
3FKN
3FKO
3FL4
3FLN
3FLQ
3FLS
3FLW
3FLY
3FLZ
3FMH
3FMJ
3FMK
3FML
3FMM
3FMN
3FSF
3FSK
3GC7
3GCP
3GCQ
3GCS
3GCU
3GCV
3GFE
3GI3
3HA8
3HEC
3HEG
3HL7
3HLL
3HP2
3HP5
3HRB
3HUB
3HUC
3HV3
3HV4
3HV5
3HV6
3HV7
3HVC
3IPH
3ITZ
3IW5
3IW6
3IW7
3IW8
3K3I
3K3J
3KF7
3KQ7
3L8S
3L8X
3LFA
3LFB
3LFC
3LFD
3LFE
3LFF
3LHJ
3MGY
3MH0
3MH1
3MH2
3MH3
3MPA
3MPT
3MVL
3MVM
3MW1
3NEW
3NNU
3NNV
3NNW
3NNX
3NWW
3O8P
3O8T
3O8U
3OBG
3OBJ
3OC1
3OCG
3OD6
3ODY
3ODZ
3OEF
3PG3
3QUD
3QUE
3RIN
3ROC
3S3I
3S4Q
3U8W
3UVP
3UVQ
3UVR
3ZS5
3ZSG
3ZSH
3ZSI
3ZYA
4A9Y
4AA0
4AA4
4AA5
4AAC
4DLI
4DLJ
4E5A
4E5B
4E6A
4E6C
4E8A
4EH2
4EH3
4EH4
4EH5
4EH6
4EH7
4EH8
4EH9
4EHV
4EWQ
4F9W
4F9Y
4FA2
4GEO
4KIN
4KIP
4KIQ
Enriched GO Terms of Interacting Partners
?
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Toll-like Receptor Signaling Pathway
Stress-induced Premature Senescence
Regulation Of Phosphorylation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
DNA Damage Checkpoint
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Innate Immune Response
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Ras Protein Signal Transduction
Cell Cycle Checkpoint
Regulation Of Innate Immune Response
Cellular Senescence
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Muscle Cell Differentiation
Myoblast Differentiation
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Ionizing Radiation
Mitochondrion Organization
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Cell Aging
Cell Cycle
Immune Response-regulating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Muscle Structure Development
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Gene Expression
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Toll-like Receptor 4 Signaling Pathway
MAPK Cascade
Signal Transduction By Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Toll-like Receptor Signaling Pathway
Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Regulation Of Metabolic Process
Cellular Response To Organic Substance
Cellular Metabolic Process
Regulation Of Phosphorylation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Metabolic Process
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of Macromolecule Biosynthetic Process
Developmental Process
Cellular Response To Growth Factor Stimulus
Response To Organic Substance
Enzyme Linked Receptor Protein Signaling Pathway
Cell Communication
Response To Growth Factor
Signaling
Positive Regulation Of Cellular Biosynthetic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Phosphorylation
Regulation Of MAP Kinase Activity
Response To Stress
Regulation Of Protein Kinase Activity
Regulation Of Signal Transduction
Anatomical Structure Development
Phosphate-containing Compound Metabolic Process
Tagcloud
?
acta2
cdh1
cdkn1a
cldn1
cldn4
cldn7
ctnnb1
fn1
krt19
mapk3
mki67
mmp2
mmp9
muc5ac
muc6
nes
pdac
pdacs
ptgs2
rps6
rps6kb1
smad4
stains
surprising
synchronous
tgfb1
tgfbr1
vim
Tagcloud (Difference)
?
acta2
cdh1
cdkn1a
cldn1
cldn4
cldn7
ctnnb1
fn1
krt19
mapk3
mki67
mmp2
mmp9
muc5ac
muc6
nes
pdac
pdacs
ptgs2
rps6
rps6kb1
smad4
stains
surprising
synchronous
tgfb1
tgfbr1
vim
Tagcloud (Intersection)
?