ZNHIT1 and KANK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNHIT1	KANK2
Description		zinc finger HIT-type containing 1	KN motif and ankyrin repeat domains 2
Image
GO Annotations	Cellular Component	Nucleosome Swr1 Complex Nucleus Nucleoplasm	Cytoplasm Mitochondrion
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Process Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Intestinal Stem Cell Homeostasis Regulation Of T Cell Proliferation Muscle Cell Differentiation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Transcription Initiation-coupled Chromatin Remodeling Calcium Ion Homeostasis Positive Regulation Of Transcription Initiation By RNA Polymerase II Hematopoietic Stem Cell Homeostasis Negative Regulation Of G0 To G1 Transition Positive Regulation Of Lymphoid Progenitor Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Podocyte Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean spheric corpuscular volume ( 32888494) Non-HDL cholesterol levels ( 32902719) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 32203549)
Interacting Genes		23 interacting genes: APP BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53	187 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CFAP68 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT31 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NRIP1 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 UBC USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1
Entrez ID		10467	25959
HPRD ID		15892	12463
Ensembl ID		ENSG00000106400	ENSG00000197256
Uniprot IDs		O43257	Q63ZY3
PDB IDs		8X15 8X19 8X1C	4HBD 5YBV 6TMD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Reactive Oxygen Species Metabolic Process MAP Kinase Activity Cellular Senescence Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Cell Cycle Process Stress-induced Premature Senescence NLRP1 Inflammasome Complex Assembly Positive Regulation Of Apoptotic Signaling Pathway Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cytokine Production Identical Protein Binding Inflammatory Response Negative Regulation Of Cell Cycle Cellular Response To UV-B Regulation Of MiRNA Processing Intracellular Signaling Cassette Necroptotic Process Regulation Of Regulatory NcRNA Processing Cellular Response To Oxygen-containing Compound Protein Serine/threonine Kinase Activity Cellular Response To UV Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition MAPK Cascade DNA Damage Checkpoint Signaling Programmed Necrotic Cell Death Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cell Population Proliferation Regulation Of Transcription By RNA Polymerase II Molecular Function Activator Activity Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA Replication Cellular Response To Light Stimulus P38MAPK Cascade Response To UV-B Stress-activated MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA-mediated Gene Silencing	Protein Binding Identical Protein Binding Nucleus Structural Constituent Of Skin Epidermis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?