TAB1 and TRAF6

Number of citations of the paper that reports this interaction (PubMedID 10094049)
0

Data Source:
HPRD (in vivo)

		TAB1	TRAF6
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	TNF receptor associated factor 6
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Membrane Protein-containing Complex	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding Molecular Adaptor Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein-macromolecule Adaptor Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development Heart Morphogenesis Cardiac Septum Development Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Lung Development Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Aorta Development Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Coronary Vasculature Development CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response DNA Damage Response Signal Transduction Canonical NF-kappaB Signal Transduction MRNA Transcription Animal Organ Morphogenesis Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II CD40 Signaling Pathway Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Defense Response To Bacterium Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Bone Remodeling Cell Development T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Protein K48-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Antiviral Innate Immune Response Intracellular Signaling Cassette Protein Branched Polyubiquitination Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Serum alkaline phosphatase levels ( 33547301) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)	Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		76 interacting genes: AATK ACAP3 APOA2 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIM26 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	184 interacting genes: ABL1 AKT1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FADD FAM177A1 FHL2 FYN GART GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK1 RIPK2 RIPK3 RNF114 RNF152 RNF31 RPL3 RPS2 RPS20 RPS27A RSAD2 SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SUFU SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TTC3 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZDHHC11 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		10454	7189
HPRD ID		04012	03833
Ensembl ID		ENSG00000100324	ENSG00000175104
Uniprot IDs		A8K6K3 Q15750	Q9Y4K3
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU 7NTH 7NTI 8GW3 8XI8 9FPD	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L 8HZ2
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction P38MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Signal Transduction Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Intracellular Signaling Cassette Negative Regulation Of Signal Transduction MAPK Cascade Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cytokine Production Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Activin Receptor Binding Positive Regulation Of Growth Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Proteolysis Regulation Of JNK Cascade Cellular Response To Growth Factor Stimulus Protein Polyubiquitination Endosome Membrane Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Immunity Protein-containing Complex Protein Metabolic Process Regulation Of Necroptotic Process TORC1 Signaling Apoptotic Process Response To Virus Positive Regulation Of Macromolecule Metabolic Process	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Defense Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Proteolysis Cytosol Activation Of Immune Response Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Polyubiquitination Positive Regulation Of Immune Response Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Defense Response Protein Kinase Activity MAPK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Signaling
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