TAB1 and TAB3

Number of citations of the paper that reports this interaction (PMID 14670075)
36

Data Source:
HPRD (in vivo)

		TAB1	TAB3
Gene Name		TGF-beta activated kinase 1/MAP3K7 binding protein 1	TGF-beta activated kinase 1/MAP3K7 binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Protein Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Catalytic Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein Complex Binding Mitogen-activated Protein Kinase P38 Binding	Protein Binding Zinc Ion Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Heart Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Lung Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		61 interactors: ACAP3 ARAP1 ASRGL1 BMPR1A C2orf44 C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 EPRS FADD FN1 GIT1 HNRNPR KIFC2 LAP3 LCMT1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 URB1 WTAP XIAP XPO7 YWHAG ZMYND11	8 interactors: CEP57L1 IKBKG MAP3K7CL PIN1 TAB1 TRAF2 TRAF6 UBC
Entrez ID		10454	257397
HPRD ID		04012	06738
Ensembl ID		ENSG00000100324	ENSG00000157625
Uniprot IDs		A8K6K3 Q15750	Q8N5C8
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L53
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorus Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Intracellular Signal Transduction Immune Response Positive Regulation Of MAP Kinase Activity Activation Of MAPK Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Signal Transduction By Phosphorylation Apoptotic Process Stress-activated MAPK Cascade	I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MAPK Cascade Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity JNK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Modification Process Activation Of NF-kappaB-inducing Kinase Activity Activation Of MAPK Activity Positive Regulation Of MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Intracellular Receptor Signaling Pathway
Tagcloud ?		5z attenuated ccr7 chemokine collectively constitutive ikappab ikk importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear	3p algorithms brdu coding confirming downregulated extracted gse54751 hcc hct hepatocellular hepg2 hypothesized ikk inverse luciferase micrornas mir mirnas mtt nearly p65 qrt rescued searching sixfold suitable tab2 targets
Tagcloud (Difference) ?		5z attenuated ccr7 chemokine collectively constitutive ikappab importantly invasion jnk jun lymphatic mb mda mediator motif o orthotopic oxozeaenol p38 phospho promotes repressed strongly suppressed tak1 tgf unclear	3p algorithms brdu coding confirming downregulated extracted gse54751 hcc hct hepatocellular hepg2 hypothesized inverse luciferase micrornas mir mirnas mtt nearly p65 qrt rescued searching sixfold suitable tab2 targets
Tagcloud (Intersection) ?		ikk