TAB1 and TAB3

Number of citations of the paper that reports this interaction (PubMedID 14670075)
20

Data Source:
HPRD (in vivo)

		TAB1	TAB3
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Membrane Protein-containing Complex	Endoplasmic Reticulum Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	In Utero Embryonic Development Heart Morphogenesis Cardiac Septum Development Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Lung Development Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Aorta Development Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Coronary Vasculature Development CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Canonical NF-kappaB Signal Transduction Response To Bacterium Negative Regulation Of Autophagy Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Serum alkaline phosphatase levels ( 33547301) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)
Interacting Genes		76 interacting genes: AATK ACAP3 APOA2 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIM26 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	12 interacting genes: AMFR CEP57L1 IKBKG MAP3K7CL OGT PIN1 PPIL3 STAT3 TAB1 TRAF2 TRAF6 UBC
Entrez ID		10454	257397
HPRD ID		04012	06738
Ensembl ID		ENSG00000100324	ENSG00000157625
Uniprot IDs		A8K6K3 Q15750	Q8N5C8
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU 7NTH 7NTI 8GW3 8XI8 9FPD
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction P38MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Signal Transduction Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Intracellular Signaling Cassette Negative Regulation Of Signal Transduction MAPK Cascade Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cytokine Production Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Activin Receptor Binding Positive Regulation Of Growth Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Proteolysis Regulation Of JNK Cascade Cellular Response To Growth Factor Stimulus Protein Polyubiquitination Endosome Membrane Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Immunity Protein-containing Complex Protein Metabolic Process Regulation Of Necroptotic Process TORC1 Signaling Apoptotic Process Response To Virus Positive Regulation Of Macromolecule Metabolic Process	Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Signaling Adaptor Activity Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process CD40 Receptor Complex Positive Regulation Of Signal Transduction Positive Regulation Of JUN Kinase Activity Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Gene Expression Negative Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Synapse Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Tumor Necrosis Factor Receptor Binding Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of MAP Kinase Activity Cytosol Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Protein Modification Process Protein-macromolecule Adaptor Activity Glutamatergic Synapse Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation
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