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TAB1 and EPRS1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
TAB1
EPRS1
Description
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
glutamyl-prolyl-tRNA synthetase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Endosome Membrane
Membrane
Protein-containing Complex
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aminoacyl-tRNA Synthetase Multienzyme Complex
GAIT Complex
Ribonucleoprotein Complex
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Kinase Activator Activity
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Mitogen-activated Protein Kinase P38 Binding
Molecular Adaptor Activity
Nucleotide Binding
RNA Binding
Catalytic Activity
Aminoacyl-tRNA Ligase Activity
Glutamate-tRNA Ligase Activity
Proline-tRNA Ligase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Ligase Activity
RNA Stem-loop Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
GTPase Binding
Biological Process
In Utero Embryonic Development
Heart Morphogenesis
Cardiac Septum Development
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
Lung Development
Positive Regulation Of Type I Interferon Production
Protein Exit From Endoplasmic Reticulum
Aorta Development
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Coronary Vasculature Development
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Translation
Regulation Of Translation
TRNA Aminoacylation For Protein Translation
Glutamyl-tRNA Aminoacylation
Prolyl-tRNA Aminoacylation
Negative Regulation Of Translation
Cellular Response To Insulin Stimulus
TRNA Aminoacylation
Cellular Response To Type II Interferon
Regulation Of Long-chain Fatty Acid Import Into Cell
Pathways
NOD1/2 Signaling Pathway
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
tRNA modification in the nucleus and cytosol
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Manganese
Glutamic acid
Proline
5'-O-(L-Prolylsulfamoyl)adenosine
5'-O-(L-Cysteinylsulfamoyl)adenosine
5'-O-(N-(Alanyl)sulfamoyl)adenosine
Diseases
GWAS
Factor VIII levels (
30586737
)
IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) (
28878392
)
IgG digalactosylation phenotypes (multivariate analysis) (
28878392
)
IgG disialylation phenotypes (multivariate analysis) (
28878392
)
IgG fucosylation phenotypes (multivariate analysis) (
28878392
)
IgG galactosylation phenotypes (multivariate analysis) (
28878392
)
IgG glycosylation (
23382691
)
IgG monogalactosylation phenotypes (multivariate analysis) (
28878392
)
IgG N-glycosylation phenotypes (multivariate analysis) (
28878392
)
IgG sialylation phenotypes (multivariate analysis) (
28878392
)
Inflammatory bowel disease (
23128233
)
Intelligence (MTAG) (
29326435
)
Schizophrenia (
29483656
)
Serum alkaline phosphatase levels (
33547301
)
Sleep duration (short sleep) (
30846698
)
vWF levels (
30586737
)
Waist circumference (
28552196
)
Interacting Genes
76 interacting genes:
AATK
ACAP3
APOA2
ARAP1
ASRGL1
BMPR1A
C9orf78
CARD11
CASP6
CDK5RAP3
CFL1
CKB
CORO1A
DBN1
DVL2
EGFR
EPRS1
ERBB4
FADD
FN1
GIT1
HNRNPR
IKBKG
ITCH
KIFC2
LAP3
LCMT1
LGALS7
LGALS7B
LNX2
MAP3K1
MAP3K7
MAPK11
MAPK14
MAPKAPK5
MICAL1
MON1A
MTG2
NR2C2
NXPH3
OGT
PDCD6IP
PHACTR3
PHC2
POLDIP2
POLR3D
PPP1R7
PPP2CB
PPP2R1A
PRKAR1A
PTPMT1
RBX1
ROR2
RPL10
RPLP1
SERPINA4
SMAD6
SMAD7
SMURF1
SNRNP35
TAB2
TAB3
TRAF2
TRAF6
TRIM26
TRIP6
TRPC4AP
TSSC4
UBC
URB1
WDCP
WTAP
XIAP
XPO7
YWHAG
ZMYND11
93 interacting genes:
AIMP2
ARL4D
BTG3
CDC42
CEBPA
DUS2
DUX4
EEF1D
HSP90AA1
HUNK
IARS1
LINC01016
LINC01554
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NEDD4
NELFCD
PTEN
RARS1
RNF10
SUMO2
SYNCRIP
TAB1
Entrez ID
10454
2058
HPRD ID
04012
00703
Ensembl ID
ENSG00000100324
ENSG00000136628
Uniprot IDs
A8K6K3
Q15750
P07814
PDB IDs
2J4O
2POM
2POP
2YDS
2YIY
4AY5
4AY6
4GS6
4KA3
4L3P
4L52
4L53
4O91
5DIY
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5NZZ
5O90
5V5N
5VVU
7NTH
7NTI
8GW3
8XI8
9FPD
1FYJ
4HVC
4K86
4K87
4K88
5A1N
5A34
5A5H
5BMU
5V58
5VAD
5Y6L
6IY6
7BBU
7F98
7F99
7F9A
7F9B
7F9C
7F9D
7OSY
7OSZ
7OT0
7OT1
7OT2
7OT3
7X09
7X1O
7Y1H
7Y1W
7Y28
7Y3S
Enriched GO Terms of Interacting Partners
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Regulation Of Intracellular Signal Transduction
P38MAPK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Signal Transduction
Regulation Of Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Intracellular Signaling Cassette
Negative Regulation Of Signal Transduction
MAPK Cascade
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Programmed Cell Death
Cytoplasm
Regulation Of Cytokine Production
Regulation Of Protein Metabolic Process
Positive Regulation Of Signaling
Negative Regulation Of Catabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Multicellular Organismal Process
Regulation Of Apoptotic Process
Activin Receptor Binding
Positive Regulation Of Growth
Positive Regulation Of Signal Transduction
Positive Regulation Of Cytokine Production
Positive Regulation Of Cell Communication
Positive Regulation Of Proteolysis
Regulation Of JNK Cascade
Cellular Response To Growth Factor Stimulus
Protein Polyubiquitination
Endosome Membrane
Regulation Of Protein Modification Process
Cell Surface Receptor Signaling Pathway
Regulation Of T Cell Mediated Immunity
Protein-containing Complex
Protein Metabolic Process
Regulation Of Necroptotic Process
TORC1 Signaling
Apoptotic Process
Response To Virus
Positive Regulation Of Macromolecule Metabolic Process
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Negative Regulation Of Metabolic Process
Extracellular Vesicle
Negative Regulation Of Translation
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Locomotion
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Cytokine Production
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Angiogenesis
Regulation Of Vasculature Development
Regulation Of MRNA Stability
Regulation Of Metabolic Process
Regulation Of Translation
Regulation Of RNA Stability
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Cell Migration
Regulation Of Endothelial Cell Migration
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Cell Motility
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Endothelial Cell Migration
Regulation Of MRNA Metabolic Process
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Tagcloud (Intersection)
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