TOMM40 and TOMM20

Number of citations of the paper that reports this interaction (PMID 15644312)
40

Data Source:
BioGRID (pull down)

		TOMM40	TOMM20
Gene Name		translocase of outer mitochondrial membrane 40 homolog (yeast)	translocase of outer mitochondrial membrane 20 homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Pore Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane ER-mitochondrion Membrane Contact Site
	Molecular Function	Protein Transmembrane Transporter Activity Porin Activity	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Unfolded Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Ion Transport Cellular Protein Metabolic Process Protein Transmembrane Transport	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Protein Transmembrane Transport
Pathways		Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS		AB1-42 ( 20932310) Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 18823527 19734902 19125160 20061627) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911) Cognitive decline ( 22054870 23207651) HDL cholesterol ( 21909109 19060911) LDL cholesterol ( 19060911) Longevity ( 21418511) Metabolic syndrome ( 22399527) Quantitative traits ( 19197348) Triglycerides ( 19060911)	Cholesterol, total ( 20686565) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: HSP90AA1 HSPA4 MTX1 PARK2 SAMM50 TOMM20 TOMM22 TOMM7	17 interactors: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 DHFR FEZ1 HAP1 KIAA1377 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1
Entrez ID		10452	9804
HPRD ID		16274	03507
Ensembl ID		ENSG00000130204	ENSG00000173726
Uniprot IDs		O96008	Q15388
PDB IDs			4APO
Enriched GO Terms of Interacting Partners?		Protein Localization To Mitochondrion Protein Targeting To Mitochondrion Mitochondrial Transport Protein Import Into Mitochondrial Outer Membrane Protein Transmembrane Transport Mitochondrion Organization Protein Localization To Organelle Establishment Of Protein Localization To Organelle Intracellular Protein Transmembrane Transport Protein Targeting Cellular Protein Localization Cytoplasmic Transport Protein Import Intracellular Protein Transport Protein Localization Mitochondrial Membrane Organization Cellular Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Organelle Organization Establishment Of Localization In Cell Establishment Of Protein Localization To Membrane Protein Localization To Membrane Transport Transmembrane Transport Chaperone-mediated Protein Complex Assembly Response To Unfolded Protein Cellular Protein Metabolic Process Membrane Organization Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination	Mitochondrial Transport Cellular Localization Regulation Of Protein Stability Establishment Of Localization In Cell Developmental Process Anatomical Structure Development Posttranscriptional Regulation Of Gene Expression Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Intracellular Transport Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Learning Mitochondrion Organization Regulation Of Mitotic Cell Cycle Cell Differentiation Cell Cycle Single-organism Behavior Negative Regulation Of Autophagy Response To Organic Cyclic Compound Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Behavioral Fear Response Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Fear Response Protein Localization To Organelle Response To Drug Axon Regeneration Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Anion Homeostasis Organ Development Regulation Of Cell Cycle Phase Transition Neuron Projection Regeneration Behavior Organelle Organization Ornithine Catabolic Process Negative Regulation Of Cellular PH Reduction Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cell Adhesion Molecule Production Learning Or Memory Protein Transmembrane Transport System Development Mitochondrial Membrane Organization
Tagcloud ?		a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion
Tagcloud (Difference) ?		a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion
Tagcloud (Intersection) ?