TOMM40 and SAMM50

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical, pull down)

		TOMM40	SAMM50
Gene Name		translocase of outer mitochondrial membrane 40 homolog (yeast)	SAMM50 sorting and assembly machinery component
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane Integral Component Of Mitochondrial Outer Membrane Pore Complex Extracellular Vesicular Exosome	Mitochondrial Sorting And Assembly Machinery Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Transmembrane Transporter Activity Porin Activity	Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Ion Transport Cellular Protein Metabolic Process Protein Transmembrane Transport	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import	Mitochondrial protein import
Drugs
Diseases
GWAS		AB1-42 ( 20932310) Age-related macular degeneration ( 22694956 23326517) Alzheimer's disease ( 22832961 18823527 19734902 19125160 20061627) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Brain imaging ( 20100581) C-reactive protein ( 22939635) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911) Cognitive decline ( 22054870 23207651) HDL cholesterol ( 21909109 19060911) LDL cholesterol ( 19060911) Longevity ( 21418511) Metabolic syndrome ( 22399527) Quantitative traits ( 19197348) Triglycerides ( 19060911)	Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Non-alcoholic fatty liver disease ( 23535911) Nonalcoholic fatty liver disease ( 22719876)
Protein-Protein Interactions		8 interactors: HSP90AA1 HSPA4 MTX1 PARK2 SAMM50 TOMM20 TOMM22 TOMM7	3 interactors: CHCHD3 MEOX2 TOMM40
Entrez ID		10452	25813
HPRD ID		16274	10826
Ensembl ID		ENSG00000130204	ENSG00000100347
Uniprot IDs		O96008	Q9Y512
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Localization To Mitochondrion Protein Targeting To Mitochondrion Mitochondrial Transport Protein Import Into Mitochondrial Outer Membrane Protein Transmembrane Transport Mitochondrion Organization Protein Localization To Organelle Establishment Of Protein Localization To Organelle Intracellular Protein Transmembrane Transport Protein Targeting Cellular Protein Localization Cytoplasmic Transport Protein Import Intracellular Protein Transport Protein Localization Mitochondrial Membrane Organization Cellular Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Organelle Organization Establishment Of Localization In Cell Establishment Of Protein Localization To Membrane Protein Localization To Membrane Transport Transmembrane Transport Chaperone-mediated Protein Complex Assembly Response To Unfolded Protein Cellular Protein Metabolic Process Membrane Organization Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination
Tagcloud ?		a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 sequenom snps transaminase triglyceride
Tagcloud (Difference) ?		a2m algorithm allele alzheimer amplicons apoe apoj bin1 biochip clut combinations cr1 determina e3 e4 epsilon2 epsilon4 exoc3l2 gab2 genotyping immobilized microchip oligonucleotides picalm predis rs11136000 sporadic studying tion	alt anthropometric apoc3 cms col13a1 consent corrections efcab4b infiltration iu nafld ncan obtaining parvb patatin pnpla3 pzp rs2073080 rs2143571 rs2228603 rs2854117 rs343062 rs6487679 rs6591182 rs738409 sequenom snps transaminase triglyceride
Tagcloud (Intersection) ?