IFITM3 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		IFITM3	GLP1R
Gene Name		interferon induced transmembrane protein 3	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Immune Response Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		2 interactors: GLP1R VKORC1	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		10410	2740
HPRD ID		05719	00677
Ensembl ID		ENSG00000142089	ENSG00000112164
Uniprot IDs		Q01628	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Vitamin K Metabolic Process Peptidyl-glutamic Acid Carboxylation CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Quinone Metabolic Process Drug Metabolic Process Cellular Response To Glucagon Stimulus Positive Regulation Of Lyase Activity Oxidation-reduction Process Response To Glucagon Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Vitamin Metabolic Process Small Molecule Metabolic Process Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Heart Contraction	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		african amphotericin cholesterol compound entry exploit green impaired influenza inhibit interestingly interferon lentiviruses monkeys mostly much overcome overcomes ph primate refractory restricted siv sivagm surprisingly transmembrane viruses	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		african amphotericin cholesterol compound entry exploit green impaired influenza inhibit interestingly interferon lentiviruses monkeys mostly much overcome overcomes ph primate refractory restricted siv sivagm surprisingly transmembrane viruses	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?