SEMA3A and NRP1

Number of citations of the paper that reports this interaction (PMID 10520994)
132

Data Source:
HPRD (in vivo)

		SEMA3A	NRP1
Gene Name		sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	neuropilin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Axon Dendrite	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Axon Growth Cone Cytoplasmic Vesicle Neuronal Cell Body Receptor Complex Sorting Endosome
	Molecular Function	Receptor Activity Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Neuron Migration Regulation Of Heart Rate Apoptotic Process Axon Guidance Axonal Fasciculation Negative Regulation Of Epithelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Olfactory Bulb Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Sympathetic Nervous System Development Dendrite Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Sensory System Development Negative Chemotaxis Axonogenesis Involved In Innervation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neural Crest Cell Migration Involved In Sympathetic Nervous System Development Facioacoustic Ganglion Development Positive Regulation Of Male Gonad Development Positive Regulation Of Neuron Migration	Angiogenesis Patterning Of Blood Vessels Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration VEGF-activated Neuropilin Signaling Pathway Otic Placode Formation Negative Regulation Of Neuron Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Ganglion Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling	Signal transduction by L1 CHL1 interactions Axon guidance Semaphorin interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Neurophilin interactions with VEGF and VEGFR L1CAM interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Iris characteristics ( 21835309) Obesity-related traits ( 23251661) Prion diseases ( 22210626)	Schizophrenia ( 21682944) Tetralogy of Fallot ( 23297363)
Protein-Protein Interactions		2 interactors: NRP1 SEMA3B	22 interactors: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		10371	8829
HPRD ID		04908	03642
Ensembl ID			ENSG00000099250
Uniprot IDs		Q14563	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9
PDB IDs			1KEX 2QQI 2QQM 2QQN 3I97 4DEQ
Enriched GO Terms of Interacting Partners?		VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Cytokine Activity Endothelial Tip Cell Fate Specification Protein Localization To Early Endosome Angiogenesis Involved In Coronary Vascular Morphogenesis Renal Artery Morphogenesis Otic Placode Formation Positive Regulation Of Retinal Ganglion Cell Axon Guidance Regulation Of Cytokine Activity VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Negative Regulation Of Cyclin Catabolic Process Ganglion Morphogenesis Axon Guidance Sensory Neuron Axon Guidance Positive Regulation Of Receptor Binding Regulation Of Retinal Ganglion Cell Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Blood Vessel Endothelial Cell Fate Specification Axonogenesis Axonogenesis Involved In Innervation Coronary Artery Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Trigeminal Nerve Structural Organization Endothelial Cell Fate Specification Ventral Trunk Neural Crest Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Axon Development Hypothalamus Cell Migration Branchiomotor Neuron Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Endothelial Cell Chemotaxis Trigeminal Ganglion Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Neuron Projection Morphogenesis Hypothalamus Cell Differentiation Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Protein Localization To Endosome Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Trigeminal Nerve Development Negative Regulation Of Axon Extension Involved In Axon Guidance Blood Vessel Endothelial Cell Differentiation	Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Locomotion Regulation Of Epithelial Cell Migration Tissue Morphogenesis Regulation Of Locomotion Blood Vessel Development Vasculature Development Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Migration Chemotaxis Positive Regulation Of Cell Proliferation Tissue Development Regulation Of Cell Motility Angiogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Movement Morphogenesis Of An Epithelium Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Ameboidal-type Cell Migration Blood Vessel Morphogenesis Regulation Of Epithelial Cell Proliferation Cell Migration Embryo Development Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Cell Motility Positive Regulation Of Cell Division Positive Regulation Of Cell Migration System Development Positive Regulation Of Cell Motility Positive Regulation Of Angiogenesis Positive Regulation Of Locomotion Regulation Of Chemotaxis Organ Development Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Cell Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Regulation Of Behavior
Tagcloud ?		cf cfs climbing elimination exuberant integrinb1 itgb1 lentivirus metabotropic mglur1 pcs picked plexina4 plexinc1 plxna4 plxnc1 purkinje redundant retrograde semaphorins shaping strengthened synapse synapses versions weakened	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		cf cfs climbing elimination exuberant integrinb1 itgb1 lentivirus metabotropic mglur1 pcs picked plexina4 plexinc1 plxna4 plxnc1 purkinje redundant retrograde semaphorins shaping strengthened synapse synapses versions weakened	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining ebi3 foxp3 helios herein neuropilin nodes pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?