SEMA3A and SEMA3B

Number of citations of the paper that reports this interaction (PMID 10196546)
27

Data Source:
HPRD (in vivo)

		SEMA3A	SEMA3B
Gene Name		sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Membrane Axon Dendrite	Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Receptor Activity
	Biological Process	Neuron Migration Regulation Of Heart Rate Apoptotic Process Axon Guidance Axonal Fasciculation Negative Regulation Of Epithelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Olfactory Bulb Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Sympathetic Nervous System Development Dendrite Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Sensory System Development Negative Chemotaxis Axonogenesis Involved In Innervation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Neural Crest Cell Migration Involved In Sympathetic Nervous System Development Facioacoustic Ganglion Development Positive Regulation Of Male Gonad Development Positive Regulation Of Neuron Migration	Cell-cell Signaling Axon Guidance
Pathways		Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Iris characteristics ( 21835309) Obesity-related traits ( 23251661) Prion diseases ( 22210626)
Protein-Protein Interactions		2 interactors: NRP1 SEMA3B	4 interactors: NRP1 NRP2 PAK6 SEMA3A
Entrez ID		10371	7869
HPRD ID		04908	03179
Ensembl ID
Uniprot IDs		Q14563	Q13214
PDB IDs
Enriched GO Terms of Interacting Partners?		VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Cytokine Activity Endothelial Tip Cell Fate Specification Protein Localization To Early Endosome Angiogenesis Involved In Coronary Vascular Morphogenesis Renal Artery Morphogenesis Otic Placode Formation Positive Regulation Of Retinal Ganglion Cell Axon Guidance Regulation Of Cytokine Activity VEGF-activated Neuropilin Signaling Pathway Vestibulocochlear Nerve Structural Organization Negative Regulation Of Cyclin Catabolic Process Ganglion Morphogenesis Axon Guidance Sensory Neuron Axon Guidance Positive Regulation Of Receptor Binding Regulation Of Retinal Ganglion Cell Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Blood Vessel Endothelial Cell Fate Specification Axonogenesis Axonogenesis Involved In Innervation Coronary Artery Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Trigeminal Nerve Structural Organization Endothelial Cell Fate Specification Ventral Trunk Neural Crest Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Axon Development Hypothalamus Cell Migration Branchiomotor Neuron Axon Guidance Hepatocyte Growth Factor Receptor Signaling Pathway Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Endothelial Cell Chemotaxis Trigeminal Ganglion Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Hepatocyte Growth Factor Stimulus Neuron Projection Morphogenesis Hypothalamus Cell Differentiation Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Protein Localization To Endosome Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Trigeminal Nerve Development Negative Regulation Of Axon Extension Involved In Axon Guidance Blood Vessel Endothelial Cell Differentiation	Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Hypothalamus Cell Differentiation Axon Extension Involved In Axon Guidance Sympathetic Ganglion Development Facial Nerve Structural Organization Facial Nerve Morphogenesis Cerebral Cortex Tangential Migration Ganglion Development Parasympathetic Nervous System Development Anatomical Structure Arrangement Sympathetic Nervous System Development Hypothalamus Development Semaphorin-plexin Signaling Pathway Forebrain Neuron Development Substrate-dependent Cell Migration Axon Extension Autonomic Nervous System Development Vestibulocochlear Nerve Structural Organization Ganglion Morphogenesis Neural Crest Cell Migration Cranial Nerve Development Sensory Neuron Axon Guidance Forebrain Neuron Differentiation Neuron Projection Extension Neural Crest Cell Development Forebrain Generation Of Neurons Neural Crest Cell Differentiation Developmental Cell Growth Axonogenesis Involved In Innervation Trigeminal Nerve Structural Organization Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Embryonic Pattern Specification Cerebral Cortex Cell Migration Diencephalon Development Nerve Development Branchiomotor Neuron Axon Guidance Limbic System Development Telencephalon Cell Migration Forebrain Cell Migration Central Nervous System Neuron Development Mesenchymal Cell Development
Tagcloud ?		cf cfs climbing elimination exuberant integrinb1 itgb1 lentivirus metabotropic mglur1 pcs picked plexina4 plexinc1 plxna4 plxnc1 purkinje redundant retrograde semaphorins shaping strengthened synapse synapses versions weakened	ags aza bgc bisulfite bsp clearly cpg demethylating deoxycytidine differentially downregulation epigenetically exploring gastric gc hypermethylation methylated methylation mgc negatively paired possess semaphorin semaphorins sgc staging status usage
Tagcloud (Difference) ?		cf cfs climbing elimination exuberant integrinb1 itgb1 lentivirus metabotropic mglur1 pcs picked plexina4 plexinc1 plxna4 plxnc1 purkinje redundant retrograde shaping strengthened synapse synapses versions weakened	ags aza bgc bisulfite bsp clearly cpg demethylating deoxycytidine differentially downregulation epigenetically exploring gastric gc hypermethylation methylated methylation mgc negatively paired possess semaphorin sgc staging status usage
Tagcloud (Intersection) ?		semaphorins