UBE4B and PRMT1

Number of citations of the paper that reports this interaction (PubMedID 29326975)
75

Data Source:
BioGRID (enzymatic study)

		UBE4B	PRMT1
Description		ubiquitination factor E4B	protein arginine methyltransferase 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Methylosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Enzyme Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone H4R3 Methyltransferase Activity Mitogen-activated Protein Kinase P38 Binding GATOR1 Complex Binding Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Protein Ubiquitination Protein Catabolic Process Neuron Projection Development Response To Endoplasmic Reticulum Stress ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation DNA Damage Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation RNA Splicing Negative Regulation Of Translation Peptidyl-arginine Methylation Viral Protein Processing BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Neuron Projection Development Cellular Response To Nutrient Levels Methylation Cellular Response To Amino Acid Starvation TORC1 Signaling Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Negative Regulation Of JNK Cascade Positive Regulation Of Hemoglobin Biosynthetic Process Cardiac Muscle Tissue Development Protein Homooligomerization Cellular Response To Methionine Protein Localization To Lysosome Membraneless Organelle Assembly Positive Regulation Of P38MAPK Cascade Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways			RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression Maturation of nucleoprotein
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Atrial fibrillation ( 29892015) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 33491795) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Resting heart rate ( 27798624)	Schizophrenia ( 29483656)
Interacting Genes		27 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A CNTN2 DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 PYCR2 RAD23A RIPK4 TP53 TRA2A TRIP12 UBE2D2 UBE2D3 VAV2 VCP	165 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEBPA CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4C1 H4C14 H4C16 HABP4 HNF4A HNRNPA1 HNRNPA3 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MAP3K5 MBD2 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PPDPF PRMT8 QKI RBM15 RELA RNF187 RPL37A RPS29 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 SRSF1 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TK1 TOPORS TP53 TRIM48 TUBB UBE4B USP11 VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZCCHC12 ZMYM5 ZNF451
Entrez ID		10277	3276
HPRD ID		11659	04257
Ensembl ID		ENSG00000130939	ENSG00000126457
Uniprot IDs		O95155	Q99873
PDB IDs		2KRE 3L1X 3L1Z 5O75	6NT2
Enriched GO Terms of Interacting Partners?		Catabolic Process Cytosol Cellular Response To Staurosporine Proteolysis DNA Damage Response Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Nucleoplasm Response To Stress Pyroptotic Inflammatory Response Positive Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death DNA Repair Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Primary Metabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Post-translational Protein Modification Positive Regulation Of Neuron Apoptotic Process Nucleic Acid Metabolic Process Macroautophagy Apoptotic Process Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling TOR Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling DNA Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development MRNA Destabilization Negative Regulation Of Cell Differentiation Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Differentiation Negative Regulation Of Cytokine Production
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