TMEM86B and OTULINL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM86B	OTULINL
Description		transmembrane protein 86B	OTU deubiquitinase with linear linkage specificity like
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Hydrolase Activity Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity D-lysine 5,6-aminomutase Activity	Protein Binding Ubiquitin-like Protein Peptidase Activity Ubiquitin Binding
	Biological Process	Lipid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process	Protein Deubiquitination
Pathways		Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469 33536424)	Asthma ( 32296059 34103634)
Interacting Genes		106 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FFAR2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22	10 interacting genes: AQP6 GOLT1A HSD17B11 JAGN1 RETREG3 SLC30A8 TMEM14B TMEM31 TMEM86B TMX2
Entrez ID		255043	54491
HPRD ID		14540	07733
Ensembl ID		ENSG00000180089	ENSG00000145569
Uniprot IDs		Q8N661	Q9NUU6
PDB IDs			6DRM
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding Membrane Fusion Mitochondrial Membrane Endomembrane System Plasma Membrane Organelle Localization By Membrane Tethering Membrane Organization Cellular Localization Vesicle Membrane Docking Vesicle Fusion Vesicle Docking Organelle Membrane Fusion SNARE Binding Golgi Vesicle Transport C-4 Methylsterol Oxidase Activity Sterol Biosynthetic Process Vesicle Organization Organelle Fusion Connexin Complex B Cell Receptor Complex Gap Junction Channel Activity Nuclear Inner Membrane Localization Within Membrane Gap Junction	Endoplasmic Reticulum Insulin Metabolic Process PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Insulin Secretion Peptide Hormone Secretion Endoplasmic Reticulum Organization Peptide Secretion D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Hormone Secretion Carbon Dioxide Transmembrane Transporter Activity Membrane Carbon Dioxide Transmembrane Transport Endoplasmic Reticulum Membrane Steroid Dehydrogenase Activity Androgen Catabolic Process Regulation Of Hormone Levels Protein Localization To Extracellular Region Granulocyte Colony-stimulating Factor Signaling Pathway Response To Monosaccharide Hormone Transport Establishment Of Protein Localization To Extracellular Region Response To Glucose Protein Secretion Amide Transport Peptide Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Zinc:proton Antiporter Activity Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Disulfide Oxidoreductase Activity Mitochondrial Membrane Hormone Metabolic Process Estrogen Biosynthetic Process Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Response To Carbohydrate Signal Release Neutrophil Differentiation Substrate Localization To Autophagosome Zinc Ion Import Across Plasma Membrane Insulin Processing Ammonium Transmembrane Transport Regulation Of Peptide Hormone Secretion Zinc Ion Import Into Organelle Golgi Cis Cisterna
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