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PSMD14 and FAM9B
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
PSMD14
FAM9B
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
family with sequence similarity 9, member B
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Nucleoplasm
Molecular Function
Metallopeptidase Activity
Metal Ion Binding
Endopeptidase Activator Activity
Proteasome Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Positive Regulation Of Endopeptidase Activity
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Proteasomal Protein Catabolic Process
Protein K63-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Androgen levels (
22936694
)
Protein-Protein Interactions
8 interactors:
ADRM1
DPY30
FAM9B
MEOX2
MITF
OLIG1
PSMD7
TXNL1
118 interactors:
ABT1
ACP6
ANKRD36B
AP1M1
ASB6
ATF7
AURKAIP1
BAG6
BARD1
BCL2A1
BET1
BLOC1S2
BYSL
C12orf10
C14orf105
C16orf72
C19orf57
C20orf195
C8orf33
CADPS
CCDC106
CCDC116
CCDC70
CDC23
CDC42EP4
CDCA7L
CENPL
CEP57L1
CEP95
CHRAC1
CLCN1
CMTM6
COL20A1
CSDE1
CWF19L2
DAPK2
DAXX
DENND2D
DNAJC15
DNAJC4
EBNA1BP2
ECH1
EIF3G
FAM161A
FASTKD3
FCHSD2
FERD3L
GFOD1
GOPC
GPX1
GSTK1
ISCU
LIN7A
LNX1
LOC728175
LYRM2
MAB21L3
MFAP1
MOB1A
MORF4L1
MORF4L2
MRPL10
MRPL28
MRPL9
MYO15B
NDE1
NDUFB10
NEBL
NOL4
PAGE1
PAGE3
PHYH
PIN4
POLL
PPP1R18
PRPF3
PSMD14
PTRH1
RAB17
RAD51B
RBM17
RBM23
RMND1
RPL9
RSL24D1
RUSC1
SDCBP
SDCBP2
SERPINE2
SFN
SLC16A3
SLPI
SMN2
SNAP29
SNAP47
SNX20
STK3
SUCLA2
SYT17
TBRG4
TCEA2
TCEANC
TCEB3
TGFBI
TRMT61B
TSG101
TUFM
TXN2
UBE2E2
URB1-AS1
XRCC4
YARS2
ZCCHC10
ZGPAT
ZNF41
ZNF410
ZNF567
ZNF614
Entrez ID
10213
171483
HPRD ID
06208
15955
Ensembl ID
ENSG00000115233
ENSG00000177138
Uniprot IDs
O00487
Q8IZU0
Q8N7Z8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Somite Specification
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Proteasome Assembly
Cell Fate Commitment
Positive Regulation Of Proteolysis
Positive Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Segment Specification
Regulation Of Nitrogen Compound Metabolic Process
Glycerol Ether Metabolic Process
Mitochondrial Translation
Organelle Organization
Translational Elongation
Vesicle Organization
Gene Expression
Mitochondrion Organization
Synaptic Vesicle Priming
Mitochondrial Translational Elongation
Translation
Establishment Of Vesicle Localization
Vesicle Localization
Ribonucleoprotein Complex Biogenesis
Establishment Of Organelle Localization
Cellular Component Assembly
Cellular Metabolic Process
Synaptic Vesicle Transport
Mitochondrial Translational Initiation
Mitochondrial Translational Termination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Extracellular Vesicular Exosome Assembly
Cellular Macromolecular Complex Assembly
Organelle Localization
Translational Termination
RNA Metabolic Process
Translational Initiation
Cellular Response To Stress
Apoptotic Signaling Pathway
Cellular Response To DNA Damage Stimulus
Membrane Organization
Protein Polyubiquitination
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Synaptic Vesicle Fusion To Presynaptic Membrane
Cellular Process
Cellular Protein Complex Disassembly
Intrinsic Apoptotic Signaling Pathway
Ribosome Biogenesis
Neurotransmitter Secretion
Macromolecule Biosynthetic Process
Vesicle Fusion
Pigmentation
Protein Complex Disassembly
Synaptic Vesicle Exocytosis
Viral Process
Cellular Pigmentation
Tagcloud
?
100nm
24h
26s
4t1
avenues
bortezomib
card10
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Difference)
?
100nm
24h
26s
4t1
avenues
bortezomib
card10
controversial
dffb
entirely
folding
grp78
ingenuity
ipa
label
lc
modulated
myeloma
noxa
nucleic
proteasomal
proteasome
proteolytic
puma
sequestosome
tceb2
top
traf3
trp53bp2
Tagcloud (Intersection)
?