PATJ and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 12021270)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PATJ	CLDN1
Description		PATJ crumbs cell polarity complex component	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Protein-containing Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly	Cell Adhesion Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Response To Ethanol Symbiont Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Tight junction interactions
Drugs
Diseases			Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		10207	9076
HPRD ID		04434	04760
Ensembl ID		ENSG00000132849	ENSG00000163347
Uniprot IDs		A0A2R8Y549 Q8NI35	A5JSJ9 O95832
PDB IDs		1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation	Bicellular Tight Junction Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Cell-cell Junction Organization Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Anchoring Junction Endothelial Cell Development Regulation Of Blood-brain Barrier Permeability Cell Junction Organization Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Apical Junction Complex Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Vascular Permeability Tight Junction Assembly Membrane Tight Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Protein Localization To Cell Junction Apical Part Of Cell Multicellular Organismal-level Homeostasis Cell Adhesion Molecule Binding Cell Junction Assembly Vascular Process In Circulatory System Cell-cell Junction Maintenance Apicolateral Plasma Membrane Circulatory System Process Plasma Membrane Regulation Of T-helper 17 Cell Differentiation Endodermal Cell Differentiation Regulation Of T-helper 17 Type Immune Response Collagen Catabolic Process Regulation Of Cell Adhesion Regulation Of Cell Fate Commitment Ovarian Follicle Development Extracellular Matrix Disassembly Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cell Junction Histone H4K8ac Reader Activity Aldosterone Secretion Regulation Of T-helper Cell Differentiation Cell Junction Maintenance Regulation Of Lymphocyte Differentiation Homeostatic Process Transmembrane Signaling Receptor Activity
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