PATJ and SCN5A

Number of citations: 54 (PubMedID 16637659)
Data Source: HPRD (in vitro)

		PATJ	SCN5A
Name		PATJ crumbs cell polarity complex component	sodium voltage-gated channel alpha subunit 5
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction	Voltage-gated Sodium Channel Complex Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Intercalated Disc Membrane Lateral Plasma Membrane Z Disc T-tubule Monoatomic Ion Channel Complex Sarcolemma Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding Fibroblast Growth Factor Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Ubiquitin Protein Ligase Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential Voltage-gated Sodium Channel Activity Involved In SA Node Cell Action Potential Scaffold Protein Binding
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly	Regulation Of Heart Rate Cardiac Conduction System Development Cardiac Ventricle Development Brainstem Development Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Response To Denervation Involved In Regulation Of Muscle Adaptation Telencephalon Development Cerebellum Development Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Action Potential Positive Regulation Of Epithelial Cell Proliferation Membrane Depolarization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Cellular Response To Calcium Ion Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell Action Potential Bundle Of His Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		None	Indecainide Ranolazine Phenytoin Topiramate Disopyramide Lidocaine Valproic acid Mexiletine Hexylcaine Cinchocaine Mephenytoin Lamotrigine Carbamazepine Moricizine Riluzole Prilocaine Ethotoin Oxcarbazepine Benzonatate Cocaine Quinidine Zonisamide Procainamide Tocainide Promethazine Chloroprocaine Propafenone Flecainide Encainide Fosphenytoin Quinidine barbiturate Ajmaline Aprindine Dronedarone Brivaracetam Vernakalant Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Isavuconazole Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		None	Atrial fibrillation Sick sinus syndrome (SSS); Sinus node dysfunction Familial idiopathic ventricular fibrillation Brugada syndrome (BRS) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445 ) Autism spectrum disorders (social interaction) ( 32624584 ) Daytime nap ( 33568662 ) Excessive daytime sleepiness ( 27992416 ) Sleep traits (multi-trait analysis) ( 27992416 ) Type 2 diabetes ( 30297969 )	Atrial fibrillation ( 29892015 30061737 ) Brugada syndrome ( 35210625 32619740 23872634 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 19389651 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) P wave duration ( 24850809 28794112 ) PR interval ( 21347284 32439900 29127183 30046033 20062060 25035420 23139255 31217584 ) PR segment duration ( 24850809 ) QRS duration ( 31217584 31251759 27577874 25035420 21076409 ) QT interval ( 29213071 29874175 19305408 24952745 19305409 ) Resting heart rate ( 27798624 ) Supraventricular ectopy ( 29618737 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) TPE interval (resting) ( 32386560 )
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	23 interacting genes: ANKS1A BANP CALM1 CBL CDK2 CRYAB DLG1 DLG2 DLG3 DLG4 EMC9 NEDD4 NEDD4L PATJ RGS2 RGS3 SNTA1 SNTB1 SNTB2 SNTG2 TEKT4 WWP2 ZMYND19
Entrez ID		10207	6331
HPRD ID		04434	02543
Ensembl ID		ENSG00000132849	ENSG00000183873
Uniprot IDs		A0A2R8Y549 Q8NI35	E9PG18 E9PHB6 H9KVD2 K4DIA1 Q14524 Q86V90
PDB IDs		1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD	2KBI 2L53 4DCK 4DJC 4JQ0 4OVN 5DBR 6LQA 6MUD 7DTC 7L83 8VYJ 8VYK
GO Terms Enriched among Interactors		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation	Ionotropic Glutamate Receptor Binding Regulation Of Potassium Ion Export Across Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Dystrophin-associated Glycoprotein Complex Transmembrane Transporter Binding Cytoplasm Negative Regulation Of Potassium Ion Export Across Plasma Membrane Neuromuscular Junction Potassium Channel Inhibitor Activity Negative Regulation Of Transmembrane Transport Receptor Localization To Synapse Receptor Clustering Negative Regulation Of Transport Regulation Of Monoatomic Cation Transmembrane Transport Protein Localization To Synapse Regulation Of Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Plasma Membrane Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Structural Molecule Activity PDZ Domain Binding Protein Localization To Cell Junction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Kinase Binding Syntrophin Complex Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Sarcolemma Regulation Of Transport Neuroligin Family Protein Binding Regulation Of Sodium Ion Transmembrane Transport Muscle System Process Protein Kinase Binding Sodium Channel Inhibitor Activity Protein Monoubiquitination GMP Kinase Activity Neuron Projection Synaptic Membrane GDP Metabolic Process Adherens Junction